Skip to main content
Journal cover image

Contributions of fat and protein to the incretin effect of a mixed meal.

Publication ,  Journal Article
Carrel, G; Egli, L; Tran, C; Schneiter, P; Giusti, V; D'Alessio, D; Tappy, L
Published in: Am J Clin Nutr
October 2011

BACKGROUND: The relative contributions of fat and protein to the incretin effect are still largely unknown. OBJECTIVE: This study assessed the incretin effects elicited by a mixed meal, and by its fat and protein components alone, with the use of a hyperglycemic clamp combined with oral nutrients. DESIGN: Eight healthy volunteers were studied over 6 h after ingestion of a sandwich containing 1) dried meat, butter, and white bread; 2) dried meat alone; 3) butter alone; or 4) no meal (fasting control). Meals were ingested during a hyperglycemic clamp, and the incretin effect was calculated as the increment in plasma insulin after food intake relative to the concentrations observed during the control study. RESULTS: A significant augmentation of postprandial insulin secretion, independent of plasma glycemia, occurred after ingestion of the mixed nutrients and the lipid component of the mixed meal (203 ± 20.7% and 167.4 ± 22.9% of control, respectively; both P < 0.05), whereas the protein component did not induce a significant incretin effect (129.0 ± 7.9% of control; P = 0.6) CONCLUSIONS: Fat ingestion, in an amount typical of a standard meal, increases insulin secretion during physiologic hyperglycemia and thus contributes to the incretin effect. In contrast, ingestion of protein typical of normal meals does not contribute to the augmentation of postprandial insulin secretion. This trial was registered at clinicaltrials.gov as NCT00869453.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Clin Nutr

DOI

EISSN

1938-3207

Publication Date

October 2011

Volume

94

Issue

4

Start / End Page

997 / 1003

Location

United States

Related Subject Headings

  • Young Adult
  • Postprandial Period
  • Nutrition & Dietetics
  • Meat
  • Male
  • Kinetics
  • Insulin
  • Incretins
  • Humans
  • Glucose Clamp Technique
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Carrel, G., Egli, L., Tran, C., Schneiter, P., Giusti, V., D’Alessio, D., & Tappy, L. (2011). Contributions of fat and protein to the incretin effect of a mixed meal. Am J Clin Nutr, 94(4), 997–1003. https://doi.org/10.3945/ajcn.111.017574
Carrel, Guillaume, Léonie Egli, Christel Tran, Philippe Schneiter, Vittorio Giusti, David D’Alessio, and Luc Tappy. “Contributions of fat and protein to the incretin effect of a mixed meal.Am J Clin Nutr 94, no. 4 (October 2011): 997–1003. https://doi.org/10.3945/ajcn.111.017574.
Carrel G, Egli L, Tran C, Schneiter P, Giusti V, D’Alessio D, et al. Contributions of fat and protein to the incretin effect of a mixed meal. Am J Clin Nutr. 2011 Oct;94(4):997–1003.
Carrel, Guillaume, et al. “Contributions of fat and protein to the incretin effect of a mixed meal.Am J Clin Nutr, vol. 94, no. 4, Oct. 2011, pp. 997–1003. Pubmed, doi:10.3945/ajcn.111.017574.
Carrel G, Egli L, Tran C, Schneiter P, Giusti V, D’Alessio D, Tappy L. Contributions of fat and protein to the incretin effect of a mixed meal. Am J Clin Nutr. 2011 Oct;94(4):997–1003.
Journal cover image

Published In

Am J Clin Nutr

DOI

EISSN

1938-3207

Publication Date

October 2011

Volume

94

Issue

4

Start / End Page

997 / 1003

Location

United States

Related Subject Headings

  • Young Adult
  • Postprandial Period
  • Nutrition & Dietetics
  • Meat
  • Male
  • Kinetics
  • Insulin
  • Incretins
  • Humans
  • Glucose Clamp Technique