Research Methods in Healthcare Epidemiology and Antimicrobial Stewardship: Randomized Controlled Trials.
Randomized controlled trials (RCT) produce the strongest level of clinical evidence when comparing interventions. RCTs are technically difficult, costly, and require specific considerations including the use of patient- and cluster-level randomization and outcome selection. In this methods paper, we focus on key considerations for RCT methods in healthcare epidemiology and antimicrobial stewardship (HE&AS) research, including the need for cluster randomization, conduct at multiple sites, behavior modification interventions, and difficulty with identifying appropriate outcomes. We review key RCTs in HE&AS with a focus on advantages and disadvantages of methods used. A checklist is provided to aid in the development of RCTs in HE&AS. Infect Control Hosp Epidemiol 2016;37:629-634.
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- Randomized Controlled Trials as Topic
- Humans
- Health Services Research
- Epidemiology
- Antimicrobial Stewardship
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 11 Medical and Health Sciences
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Randomized Controlled Trials as Topic
- Humans
- Health Services Research
- Epidemiology
- Antimicrobial Stewardship
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 11 Medical and Health Sciences