Vesicoureteral reflux and the extracellular matrix connection.
Publication
, Journal Article
Tokhmafshan, F; Brophy, PD; Gbadegesin, RA; Gupta, IR
Published in: Pediatr Nephrol
April 2017
Primary vesicoureteral reflux (VUR) is a common pediatric condition due to a developmental defect in the ureterovesical junction. The prevalence of VUR among individuals with connective tissue disorders, as well as the importance of the ureter and bladder wall musculature for the anti-reflux mechanism, suggest that defects in the extracellular matrix (ECM) within the ureterovesical junction may result in VUR. This review will discuss the function of the smooth muscle and its supporting ECM microenvironment with respect to VUR, and explore the association of VUR with mutations in ECM-related genes.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Pediatr Nephrol
DOI
EISSN
1432-198X
Publication Date
April 2017
Volume
32
Issue
4
Start / End Page
565 / 576
Location
Germany
Related Subject Headings
- Vesico-Ureteral Reflux
- Urology & Nephrology
- Humans
- Extracellular Matrix
- Child
- 3213 Paediatrics
- 3202 Clinical sciences
- 1114 Paediatrics and Reproductive Medicine
Citation
APA
Chicago
ICMJE
MLA
NLM
Tokhmafshan, F., Brophy, P. D., Gbadegesin, R. A., & Gupta, I. R. (2017). Vesicoureteral reflux and the extracellular matrix connection. Pediatr Nephrol, 32(4), 565–576. https://doi.org/10.1007/s00467-016-3386-5
Tokhmafshan, Fatima, Patrick D. Brophy, Rasheed A. Gbadegesin, and Indra R. Gupta. “Vesicoureteral reflux and the extracellular matrix connection.” Pediatr Nephrol 32, no. 4 (April 2017): 565–76. https://doi.org/10.1007/s00467-016-3386-5.
Tokhmafshan F, Brophy PD, Gbadegesin RA, Gupta IR. Vesicoureteral reflux and the extracellular matrix connection. Pediatr Nephrol. 2017 Apr;32(4):565–76.
Tokhmafshan, Fatima, et al. “Vesicoureteral reflux and the extracellular matrix connection.” Pediatr Nephrol, vol. 32, no. 4, Apr. 2017, pp. 565–76. Pubmed, doi:10.1007/s00467-016-3386-5.
Tokhmafshan F, Brophy PD, Gbadegesin RA, Gupta IR. Vesicoureteral reflux and the extracellular matrix connection. Pediatr Nephrol. 2017 Apr;32(4):565–576.
Published In
Pediatr Nephrol
DOI
EISSN
1432-198X
Publication Date
April 2017
Volume
32
Issue
4
Start / End Page
565 / 576
Location
Germany
Related Subject Headings
- Vesico-Ureteral Reflux
- Urology & Nephrology
- Humans
- Extracellular Matrix
- Child
- 3213 Paediatrics
- 3202 Clinical sciences
- 1114 Paediatrics and Reproductive Medicine