In Vivo Selection Against Human Colorectal Cancer Xenografts Identifies an Aptamer That Targets RNA Helicase Protein DHX9.
Publication
, Journal Article
Mi, J; Ray, P; Liu, J; Kuan, C-T; Xu, J; Hsu, D; Sullenger, BA; White, RR; Clary, BM
Published in: Mol Ther Nucleic Acids
April 26, 2016
The ability to selectively target disease-related tissues with molecules is critical to the design of effective therapeutic and diagnostic reagents. Recognizing the differences between the in vivo environment and in vitro conditions, we employed an in vivo selection strategy to identify RNA aptamers (targeting motifs) that could localize to tumor in situ. One of the selected molecules is an aptamer that binds to the protein DHX9, an RNA helicase that is known to be upregulated in colorectal cancer. Upon systemic administration, the aptamer preferentially localized to the nucleus of cancer cells in vivo and thus has the potential to be used for targeted delivery.
Duke Scholars
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Published In
Mol Ther Nucleic Acids
DOI
ISSN
2162-2531
Publication Date
April 26, 2016
Volume
5
Issue
4
Start / End Page
e315
Location
United States
Related Subject Headings
- 3101 Biochemistry and cell biology
- 1103 Clinical Sciences
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Mi, J., Ray, P., Liu, J., Kuan, C.-T., Xu, J., Hsu, D., … Clary, B. M. (2016). In Vivo Selection Against Human Colorectal Cancer Xenografts Identifies an Aptamer That Targets RNA Helicase Protein DHX9. Mol Ther Nucleic Acids, 5(4), e315. https://doi.org/10.1038/mtna.2016.27
Mi, Jing, Partha Ray, Jenny Liu, Chien-Tsun Kuan, Jennifer Xu, David Hsu, Bruce A. Sullenger, Rebekah R. White, and Bryan M. Clary. “In Vivo Selection Against Human Colorectal Cancer Xenografts Identifies an Aptamer That Targets RNA Helicase Protein DHX9.” Mol Ther Nucleic Acids 5, no. 4 (April 26, 2016): e315. https://doi.org/10.1038/mtna.2016.27.
Mi J, Ray P, Liu J, Kuan C-T, Xu J, Hsu D, et al. In Vivo Selection Against Human Colorectal Cancer Xenografts Identifies an Aptamer That Targets RNA Helicase Protein DHX9. Mol Ther Nucleic Acids. 2016 Apr 26;5(4):e315.
Mi, Jing, et al. “In Vivo Selection Against Human Colorectal Cancer Xenografts Identifies an Aptamer That Targets RNA Helicase Protein DHX9.” Mol Ther Nucleic Acids, vol. 5, no. 4, Apr. 2016, p. e315. Pubmed, doi:10.1038/mtna.2016.27.
Mi J, Ray P, Liu J, Kuan C-T, Xu J, Hsu D, Sullenger BA, White RR, Clary BM. In Vivo Selection Against Human Colorectal Cancer Xenografts Identifies an Aptamer That Targets RNA Helicase Protein DHX9. Mol Ther Nucleic Acids. 2016 Apr 26;5(4):e315.
Published In
Mol Ther Nucleic Acids
DOI
ISSN
2162-2531
Publication Date
April 26, 2016
Volume
5
Issue
4
Start / End Page
e315
Location
United States
Related Subject Headings
- 3101 Biochemistry and cell biology
- 1103 Clinical Sciences
- 0601 Biochemistry and Cell Biology