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Biomarkers and recent advances in the management and therapy of sickle cell disease.

Publication ,  Journal Article
Telen, MJ
Published in: F1000Res
2015

Although production of hemoglobin S, the genetic defect that causes sickle cell disease (SCD), directly affects only red blood cells, the manifestations of SCD are pervasive, and almost every cell type and organ system in the body can be involved. Today, the vast majority of patients with SCD who receive modern health care reach adulthood thanks to vaccine prophylaxis and improvements in supportive care, including transfusion. However, once patients reach adulthood, they commonly experience recurrent painful vaso-occlusive crises and frequently have widespread end-organ damage and severely shortened life expectancies. Over the last several decades, research has elucidated many of the mechanisms whereby abnormal red blood cells produce such ubiquitous organ damage. With these discoveries have come new ways to measure disease activity. In addition, new pharmaceutical interventions are now being developed to address what has been learned about disease mechanisms.

Duke Scholars

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Published In

F1000Res

DOI

ISSN

2046-1402

Publication Date

2015

Volume

4

Location

England

Related Subject Headings

  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
  • 0601 Biochemistry and Cell Biology
 

Citation

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Telen, M. J. (2015). Biomarkers and recent advances in the management and therapy of sickle cell disease. F1000Res, 4. https://doi.org/10.12688/f1000research.6615.1
Telen, Marilyn J. “Biomarkers and recent advances in the management and therapy of sickle cell disease.F1000Res 4 (2015). https://doi.org/10.12688/f1000research.6615.1.
Telen, Marilyn J. “Biomarkers and recent advances in the management and therapy of sickle cell disease.F1000Res, vol. 4, 2015. Pubmed, doi:10.12688/f1000research.6615.1.

Published In

F1000Res

DOI

ISSN

2046-1402

Publication Date

2015

Volume

4

Location

England

Related Subject Headings

  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
  • 0601 Biochemistry and Cell Biology