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Once-daily bedtime dosing regimen of cimetidine in the treatment of gastric ulcer.

Publication ,  Journal Article
Frank, WO; Young, M; Palmer, RH; Karlstadt, R; Rockhold, F; Mounce, W
Published in: Clin Ther
1989

In a double-blind study of 163 patients with benign chronic gastric ulcer, 83 were randomly assigned to receive 800 mg of cimetidine once daily at bedtime for six weeks and 80 received placebo. After six weeks of treatment, the ulcers were healed in 76% of the cimetidine-treated patients and in 55% of the placebo group (P less than 0.003). Within two weeks of starting cimetidine treatment, over 60% of the patients were without daytime or nighttime pain. At six weeks. 77% of the cimetidine-treated patients and 67% of the placebo group were without daytime pain and 89% and 74% (P less than 0.05), respectively, were without nighttime pain. The proportion of pain-free nights and days increased each week in the cimetidine-treated patients. Transient and self-limited adverse experiences were reported by 13% of the cimetidine-treated patients and by 15% of the placebo group. The results achieved in the present study with a once-daily, bedtime dose of cimetidine are similar to those seen in patients given cimetidine twice and four times daily.

Duke Scholars

Published In

Clin Ther

ISSN

0149-2918

Publication Date

1989

Volume

11

Issue

5

Start / End Page

595 / 603

Location

United States

Related Subject Headings

  • Stomach Ulcer
  • Randomized Controlled Trials as Topic
  • Pain
  • Optoelectronics & Photonics
  • Multicenter Studies as Topic
  • Middle Aged
  • Male
  • Humans
  • Female
  • Double-Blind Method
 

Citation

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MLA
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Frank, W. O., Young, M., Palmer, R. H., Karlstadt, R., Rockhold, F., & Mounce, W. (1989). Once-daily bedtime dosing regimen of cimetidine in the treatment of gastric ulcer. Clin Ther, 11(5), 595–603.
Frank, W. O., M. Young, R. H. Palmer, R. Karlstadt, F. Rockhold, and W. Mounce. “Once-daily bedtime dosing regimen of cimetidine in the treatment of gastric ulcer.Clin Ther 11, no. 5 (1989): 595–603.
Frank WO, Young M, Palmer RH, Karlstadt R, Rockhold F, Mounce W. Once-daily bedtime dosing regimen of cimetidine in the treatment of gastric ulcer. Clin Ther. 1989;11(5):595–603.
Frank, W. O., et al. “Once-daily bedtime dosing regimen of cimetidine in the treatment of gastric ulcer.Clin Ther, vol. 11, no. 5, 1989, pp. 595–603.
Frank WO, Young M, Palmer RH, Karlstadt R, Rockhold F, Mounce W. Once-daily bedtime dosing regimen of cimetidine in the treatment of gastric ulcer. Clin Ther. 1989;11(5):595–603.
Journal cover image

Published In

Clin Ther

ISSN

0149-2918

Publication Date

1989

Volume

11

Issue

5

Start / End Page

595 / 603

Location

United States

Related Subject Headings

  • Stomach Ulcer
  • Randomized Controlled Trials as Topic
  • Pain
  • Optoelectronics & Photonics
  • Multicenter Studies as Topic
  • Middle Aged
  • Male
  • Humans
  • Female
  • Double-Blind Method