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Fatigue and Oxidative Stress in Children Undergoing Leukemia Treatment.

Publication ,  Journal Article
Rodgers, C; Sanborn, C; Taylor, O; Gundy, P; Pasvogel, A; Moore, IMK; Hockenberry, MJ
Published in: Biological research for nursing
October 2016

Fatigue is a frequent and distressing symptom in children undergoing leukemia treatment; however, little is known about factors influencing this symptom. Antioxidants such as glutathione can decrease symptom severity in adult oncology patients, but no study has evaluated antioxidants' effects on symptoms in pediatric oncology patients. This study describes fatigue patterns and associations of fatigue with antioxidants represented by reduced glutathione (GSH) and the reduced/oxidized glutathione (GSH/GSSG) ratio among children receiving leukemia treatment. A repeated measures design assessed fatigue and antioxidants among 38 children from two large U.S. cancer centers. Fatigue was assessed among school-age children and by parent proxy among young children. Antioxidants (GSH and GSH/GSSG ratio) were assessed from cerebrospinal fluid at four phases during leukemia treatment. Young children had a steady decline of fatigue from the end of induction treatment through the continuation phase of treatment, but no significant changes were noted among the school-age children. Mean antioxidant scores varied slightly over time; however, the GSH/GSSG ratios in these children were significantly lower than the normal ratio. Mean GSH/GSSG ratios significantly correlated to fatigue scores of the school-age children during early phases of treatment. Children with low mean GSH/GSSG ratios demonstrated oxidative stress. The low ratios noted early in therapy were significantly correlated with higher fatigue scores during induction and postinduction treatment phases. This finding suggests that increased oxidative stress during the more intensive phases of therapy may explain the experience of fatigue children report.

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Published In

Biological research for nursing

DOI

EISSN

1552-4175

ISSN

1099-8004

Publication Date

October 2016

Volume

18

Issue

5

Start / End Page

515 / 520

Related Subject Headings

  • United States
  • Oxidative Stress
  • Nursing
  • Male
  • Leukemia
  • Infant
  • Humans
  • Glutathione
  • Female
  • Fatigue
 

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Rodgers, C., Sanborn, C., Taylor, O., Gundy, P., Pasvogel, A., Moore, I. M. K., & Hockenberry, M. J. (2016). Fatigue and Oxidative Stress in Children Undergoing Leukemia Treatment. Biological Research for Nursing, 18(5), 515–520. https://doi.org/10.1177/1099800416647794
Rodgers, Cheryl, Chelse Sanborn, Olga Taylor, Patricia Gundy, Alice Pasvogel, Ida M Ki Moore, and Marilyn J. Hockenberry. “Fatigue and Oxidative Stress in Children Undergoing Leukemia Treatment.Biological Research for Nursing 18, no. 5 (October 2016): 515–20. https://doi.org/10.1177/1099800416647794.
Rodgers C, Sanborn C, Taylor O, Gundy P, Pasvogel A, Moore IMK, et al. Fatigue and Oxidative Stress in Children Undergoing Leukemia Treatment. Biological research for nursing. 2016 Oct;18(5):515–20.
Rodgers, Cheryl, et al. “Fatigue and Oxidative Stress in Children Undergoing Leukemia Treatment.Biological Research for Nursing, vol. 18, no. 5, Oct. 2016, pp. 515–20. Epmc, doi:10.1177/1099800416647794.
Rodgers C, Sanborn C, Taylor O, Gundy P, Pasvogel A, Moore IMK, Hockenberry MJ. Fatigue and Oxidative Stress in Children Undergoing Leukemia Treatment. Biological research for nursing. 2016 Oct;18(5):515–520.
Journal cover image

Published In

Biological research for nursing

DOI

EISSN

1552-4175

ISSN

1099-8004

Publication Date

October 2016

Volume

18

Issue

5

Start / End Page

515 / 520

Related Subject Headings

  • United States
  • Oxidative Stress
  • Nursing
  • Male
  • Leukemia
  • Infant
  • Humans
  • Glutathione
  • Female
  • Fatigue