Skip to main content
Journal cover image

Respiratory syncytial virus hospitalisation trends in children with haemodynamically significant heart disease, 1997-2012.

Publication ,  Journal Article
Chu, PY; Hornik, CP; Li, JS; Campbell, MJ; Hill, KD
Published in: Cardiol Young
January 2017

OBJECTIVE: The aim of the study was to evaluate the trends in respiratory syncytial virus-related hospitalisations and associated outcomes in children with haemodynamically significant heart disease in the United States of America. Study design The Kids' Inpatient Databases (1997-2012) were used to estimate the incidence of respiratory syncytial virus hospitalisation among children ⩽24 months with or without haemodynamically significant heart disease. Weighted multivariable logistic regression and chi-square tests were used to evaluate the trends over time and factors associated with hospitalisation, comparing eras before and after publication of the 2003 American Academy of Pediatrics palivizumab immunoprophylaxis guidelines. Secondary outcomes included in-hospital mortality, morbidity, length of stay, and cost. RESULTS: Overall, 549,265 respiratory syncytial virus-related hospitalisations were evaluated, including 2518 (0.5%) in children with haemodynamically significant heart disease. The incidence of respiratory syncytial virus hospitalisation in children with haemodynamically significant heart disease decreased by 36% when comparing pre- and post-palivizumab guideline eras versus an 8% decline in children without haemodynamically significant heart disease (p<0.001). Children with haemodynamically significant heart disease had higher rates of respiratory syncytial virus-associated mortality (4.9 versus 0.1%, p<0.001) and morbidity (31.5 versus 3.5%, p<0.001) and longer hospital length of stay (17.9 versus 3.9 days, p<0.001) compared with children without haemodynamically significant heart disease. The mean cost of respiratory syncytial virus hospitalisation in 2009 was $58,166 (95% CI:$46,017, $70,315). CONCLUSIONS: These data provide stakeholders with a means to evaluate the cost-utility of various immunoprophylaxis strategies.

Duke Scholars

Published In

Cardiol Young

DOI

EISSN

1467-1107

Publication Date

January 2017

Volume

27

Issue

1

Start / End Page

16 / 25

Location

England

Related Subject Headings

  • United States
  • Retrospective Studies
  • Respiratory Syncytial Viruses
  • Respiratory Syncytial Virus Infections
  • Male
  • Infant
  • Incidence
  • Humans
  • Hospitalization
  • Hospital Mortality
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chu, P. Y., Hornik, C. P., Li, J. S., Campbell, M. J., & Hill, K. D. (2017). Respiratory syncytial virus hospitalisation trends in children with haemodynamically significant heart disease, 1997-2012. Cardiol Young, 27(1), 16–25. https://doi.org/10.1017/S1047951116000470
Chu, Patricia Y., Christoph P. Hornik, Jennifer S. Li, Michael J. Campbell, and Kevin D. Hill. “Respiratory syncytial virus hospitalisation trends in children with haemodynamically significant heart disease, 1997-2012.Cardiol Young 27, no. 1 (January 2017): 16–25. https://doi.org/10.1017/S1047951116000470.
Chu PY, Hornik CP, Li JS, Campbell MJ, Hill KD. Respiratory syncytial virus hospitalisation trends in children with haemodynamically significant heart disease, 1997-2012. Cardiol Young. 2017 Jan;27(1):16–25.
Chu, Patricia Y., et al. “Respiratory syncytial virus hospitalisation trends in children with haemodynamically significant heart disease, 1997-2012.Cardiol Young, vol. 27, no. 1, Jan. 2017, pp. 16–25. Pubmed, doi:10.1017/S1047951116000470.
Chu PY, Hornik CP, Li JS, Campbell MJ, Hill KD. Respiratory syncytial virus hospitalisation trends in children with haemodynamically significant heart disease, 1997-2012. Cardiol Young. 2017 Jan;27(1):16–25.
Journal cover image

Published In

Cardiol Young

DOI

EISSN

1467-1107

Publication Date

January 2017

Volume

27

Issue

1

Start / End Page

16 / 25

Location

England

Related Subject Headings

  • United States
  • Retrospective Studies
  • Respiratory Syncytial Viruses
  • Respiratory Syncytial Virus Infections
  • Male
  • Infant
  • Incidence
  • Humans
  • Hospitalization
  • Hospital Mortality