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Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease.

Publication ,  Journal Article
Pilla-Moffett, D; Barber, MF; Taylor, GA; Coers, J
Published in: J Mol Biol
August 28, 2016

Cell-autonomous immunity is essential for host organisms to defend themselves against invasive microbes. In vertebrates, both the adaptive and the innate branches of the immune system operate cell-autonomous defenses as key effector mechanisms that are induced by pro-inflammatory interferons (IFNs). IFNs can activate cell-intrinsic host defenses in virtually any cell type ranging from professional phagocytes to mucosal epithelial cells. Much of this IFN-induced host resistance program is dependent on four families of IFN-inducible GTPases: the myxovirus resistance proteins, the immunity-related GTPases, the guanylate-binding proteins (GBPs), and the very large IFN-inducible GTPases. These GTPase families provide host resistance to a variety of viral, bacterial, and protozoan pathogens through the sequestration of microbial proteins, manipulation of vesicle trafficking, regulation of antimicrobial autophagy (xenophagy), execution of intracellular membranolytic pathways, and the activation of inflammasomes. This review discusses our current knowledge of the molecular function of IFN-inducible GTPases in providing host resistance, as well as their role in the pathogenesis of autoinflammatory Crohn's disease. While substantial advances were made in the recent past, few of the known functions of IFN-inducible GTPases have been explored in any depth, and new functions await discovery. This review will therefore highlight key areas of future exploration that promise to advance our understanding of the role of IFN-inducible GTPases in human diseases.

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Published In

J Mol Biol

DOI

EISSN

1089-8638

Publication Date

August 28, 2016

Volume

428

Issue

17

Start / End Page

3495 / 3513

Location

Netherlands

Related Subject Headings

  • Viruses
  • Virus Diseases
  • Vertebrates
  • Interferons
  • Inflammation
  • Immunity, Innate
  • Humans
  • GTP Phosphohydrolases
  • Disease Resistance
  • Biochemistry & Molecular Biology
 

Citation

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Pilla-Moffett, D., Barber, M. F., Taylor, G. A., & Coers, J. (2016). Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease. J Mol Biol, 428(17), 3495–3513. https://doi.org/10.1016/j.jmb.2016.04.032
Pilla-Moffett, Danielle, Matthew F. Barber, Gregory A. Taylor, and Jörn Coers. “Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease.J Mol Biol 428, no. 17 (August 28, 2016): 3495–3513. https://doi.org/10.1016/j.jmb.2016.04.032.
Pilla-Moffett D, Barber MF, Taylor GA, Coers J. Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease. J Mol Biol. 2016 Aug 28;428(17):3495–513.
Pilla-Moffett, Danielle, et al. “Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease.J Mol Biol, vol. 428, no. 17, Aug. 2016, pp. 3495–513. Pubmed, doi:10.1016/j.jmb.2016.04.032.
Pilla-Moffett D, Barber MF, Taylor GA, Coers J. Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease. J Mol Biol. 2016 Aug 28;428(17):3495–3513.
Journal cover image

Published In

J Mol Biol

DOI

EISSN

1089-8638

Publication Date

August 28, 2016

Volume

428

Issue

17

Start / End Page

3495 / 3513

Location

Netherlands

Related Subject Headings

  • Viruses
  • Virus Diseases
  • Vertebrates
  • Interferons
  • Inflammation
  • Immunity, Innate
  • Humans
  • GTP Phosphohydrolases
  • Disease Resistance
  • Biochemistry & Molecular Biology