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Abstract 3405: MicroRNA expression characterizes oligometastasis(es)

Publication ,  Journal Article
Xing, RH; Lussier, YA; Salama, JK; Khodarev, NN; Huang, Y; Zhang, Q; Khan, SA; Yang, X; Hasselle, MD; Darga, TE; Malik, R; Fan, H; Perakis, S ...
Published in: Cancer Research
April 15, 2012

Background: Cancer staging and treatment presumes a division into localized or metastatic disease. We proposed an intermediate state defined by β5 cumulative metastasis(es), termed oligometastases. In contrast to widespread polymetastases, oligometastatic patients may benefit from metastasis-directed local treatments. However, many patients who initially present with oligometastases progress to polymetastases. Predictors of progression could improve patient selection for metastasis-directed therapy. Methods: Here, we identified patterns of microRNA expression of tumor samples from oligometastatic patients treated with high-dose radiotherapy. Results: Patients who failed to develop polymetastases are characterized by unique prioritized features of a microRNA classifier that includes the microRNA-200 family. We created an oligometastatic-polymetastatic xenograft model in which the patient-derived microRNAs discriminated between the two metastatic outcomes. MicroRNA-200c enhancement in an oligometastatic cell line resulted in polymetastatic progression. Conclusions: These results demonstrate a biological basis for oligometastases and a potential for using microRNA expression to identify patients most likely to remain oligometastatic after metastasis-directed treatment.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3405. doi:1538-7445.AM2012-3405

Duke Scholars

Published In

Cancer Research

DOI

EISSN

1538-7445

ISSN

0008-5472

Publication Date

April 15, 2012

Volume

72

Issue

8_Supplement

Start / End Page

3405 / 3405

Publisher

American Association for Cancer Research (AACR)

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Xing, R. H., Lussier, Y. A., Salama, J. K., Khodarev, N. N., Huang, Y., Zhang, Q., … Weichselbaum, R. R. (2012). Abstract 3405: MicroRNA expression characterizes oligometastasis(es). Cancer Research, 72(8_Supplement), 3405–3405. https://doi.org/10.1158/1538-7445.am2012-3405
Xing, Rosie Hongmei, Yves A. Lussier, Joseph K. Salama, Nikolai N. Khodarev, Yong Huang, Qingbei Zhang, Sajid A. Khan, et al. “Abstract 3405: MicroRNA expression characterizes oligometastasis(es).” Cancer Research 72, no. 8_Supplement (April 15, 2012): 3405–3405. https://doi.org/10.1158/1538-7445.am2012-3405.
Xing RH, Lussier YA, Salama JK, Khodarev NN, Huang Y, Zhang Q, et al. Abstract 3405: MicroRNA expression characterizes oligometastasis(es). Cancer Research. 2012 Apr 15;72(8_Supplement):3405–3405.
Xing, Rosie Hongmei, et al. “Abstract 3405: MicroRNA expression characterizes oligometastasis(es).” Cancer Research, vol. 72, no. 8_Supplement, American Association for Cancer Research (AACR), Apr. 2012, pp. 3405–3405. Crossref, doi:10.1158/1538-7445.am2012-3405.
Xing RH, Lussier YA, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman S, Weichselbaum RR. Abstract 3405: MicroRNA expression characterizes oligometastasis(es). Cancer Research. American Association for Cancer Research (AACR); 2012 Apr 15;72(8_Supplement):3405–3405.

Published In

Cancer Research

DOI

EISSN

1538-7445

ISSN

0008-5472

Publication Date

April 15, 2012

Volume

72

Issue

8_Supplement

Start / End Page

3405 / 3405

Publisher

American Association for Cancer Research (AACR)

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis