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Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'.

Publication ,  Journal Article
Roland, B; Jordan, R; Sosulski, DL; Diodato, A; Fukunaga, I; Wickersham, I; Franks, KM; Schaefer, AT; Fleischmann, A
Published in: Elife
May 13, 2016

Perturbations in neural circuits can provide mechanistic understanding of the neural correlates of behavior. In M71 transgenic mice with a "monoclonal nose", glomerular input patterns in the olfactory bulb are massively perturbed and olfactory behaviors are altered. To gain insights into how olfactory circuits can process such degraded inputs we characterized odor-evoked responses of olfactory bulb mitral cells and interneurons. Surprisingly, calcium imaging experiments reveal that mitral cell responses in M71 transgenic mice are largely normal, highlighting a remarkable capacity of olfactory circuits to normalize sensory input. In vivo whole cell recordings suggest that feedforward inhibition from olfactory bulb periglomerular cells can mediate this signal normalization. Together, our results identify inhibitory circuits in the olfactory bulb as a mechanistic basis for many of the behavioral phenotypes of mice with a "monoclonal nose" and highlight how substantially degraded odor input can be transformed to yield meaningful olfactory bulb output.

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Published In

Elife

DOI

EISSN

2050-084X

Publication Date

May 13, 2016

Volume

5

Location

England

Related Subject Headings

  • Olfactory Bulb
  • Olfaction Disorders
  • Neurons
  • Nerve Net
  • Mice, Transgenic
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 0601 Biochemistry and Cell Biology
 

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Roland, B., Jordan, R., Sosulski, D. L., Diodato, A., Fukunaga, I., Wickersham, I., … Fleischmann, A. (2016). Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'. Elife, 5. https://doi.org/10.7554/eLife.16335
Roland, Benjamin, Rebecca Jordan, Dara L. Sosulski, Assunta Diodato, Izumi Fukunaga, Ian Wickersham, Kevin M. Franks, Andreas T. Schaefer, and Alexander Fleischmann. “Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'.Elife 5 (May 13, 2016). https://doi.org/10.7554/eLife.16335.
Roland B, Jordan R, Sosulski DL, Diodato A, Fukunaga I, Wickersham I, et al. Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'. Elife. 2016 May 13;5.
Roland, Benjamin, et al. “Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'.Elife, vol. 5, May 2016. Pubmed, doi:10.7554/eLife.16335.
Roland B, Jordan R, Sosulski DL, Diodato A, Fukunaga I, Wickersham I, Franks KM, Schaefer AT, Fleischmann A. Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'. Elife. 2016 May 13;5.

Published In

Elife

DOI

EISSN

2050-084X

Publication Date

May 13, 2016

Volume

5

Location

England

Related Subject Headings

  • Olfactory Bulb
  • Olfaction Disorders
  • Neurons
  • Nerve Net
  • Mice, Transgenic
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 0601 Biochemistry and Cell Biology