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Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps.

Publication ,  Journal Article
Mentz, RJ; Roessig, L; Greenberg, BH; Sato, N; Shinagawa, K; Yeo, D; Kwok, BWK; Reyes, EB; Krum, H; Pieske, B; Greene, SJ; Ambrosy, AP ...
Published in: JACC Heart Fail
June 2016

Heart failure (HF) is a major and increasing global public health problem. In Asia, aging populations and recent increases in cardiovascular risk factors have contributed to a particularly high burden of HF, with outcomes that are poorer than those in the rest of the world. Representation of Asians in landmark HF trials has been variable. In addition, HF patients from Asia demonstrate clinical differences from patients in other geographic regions. Thus, the generalizability of some clinical trial results to the Asian population remains uncertain. In this article, we review differences in HF phenotype, HF management, and outcomes in patients from East and Southeast Asia. We describe lessons learned in Asia from recent HF registries and clinical trial databases and outline strategies to improve the potential for success in future trials. This review is based on discussions among scientists, clinical trialists, industry representatives, and regulatory representatives at the CardioVascular Clinical Trialist Asia Forum in Singapore on July 4, 2014.

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Published In

JACC Heart Fail

DOI

EISSN

2213-1787

Publication Date

June 2016

Volume

4

Issue

6

Start / End Page

419 / 427

Location

United States

Related Subject Headings

  • Phenotype
  • Humans
  • Heart Failure
  • Clinical Trials as Topic
  • Asian People
  • Asia, Southeastern
  • Asia, Eastern
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Mentz, R. J., Roessig, L., Greenberg, B. H., Sato, N., Shinagawa, K., Yeo, D., … Lam, C. S. P. (2016). Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps. JACC Heart Fail, 4(6), 419–427. https://doi.org/10.1016/j.jchf.2016.01.013
Mentz, Robert J., Lothar Roessig, Barry H. Greenberg, Naoki Sato, Kaori Shinagawa, Daniel Yeo, Bernard W. K. Kwok, et al. “Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps.JACC Heart Fail 4, no. 6 (June 2016): 419–27. https://doi.org/10.1016/j.jchf.2016.01.013.
Mentz RJ, Roessig L, Greenberg BH, Sato N, Shinagawa K, Yeo D, et al. Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps. JACC Heart Fail. 2016 Jun;4(6):419–27.
Mentz, Robert J., et al. “Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps.JACC Heart Fail, vol. 4, no. 6, June 2016, pp. 419–27. Pubmed, doi:10.1016/j.jchf.2016.01.013.
Mentz RJ, Roessig L, Greenberg BH, Sato N, Shinagawa K, Yeo D, Kwok BWK, Reyes EB, Krum H, Pieske B, Greene SJ, Ambrosy AP, Kelly JP, Zannad F, Pitt B, Lam CSP. Heart Failure Clinical Trials in East and Southeast Asia: Understanding the Importance and Defining the Next Steps. JACC Heart Fail. 2016 Jun;4(6):419–427.
Journal cover image

Published In

JACC Heart Fail

DOI

EISSN

2213-1787

Publication Date

June 2016

Volume

4

Issue

6

Start / End Page

419 / 427

Location

United States

Related Subject Headings

  • Phenotype
  • Humans
  • Heart Failure
  • Clinical Trials as Topic
  • Asian People
  • Asia, Southeastern
  • Asia, Eastern
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology