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mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development.

Publication ,  Journal Article
Wang, H-X; Cheng, JS; Chu, S; Qiu, Y-R; Zhong, X-P
Published in: J Immunol
July 1, 2016

Thymic epithelial cells (TECs) play important roles in T cell generation. Mechanisms that control TEC development and function are still not well defined. The mammalian or mechanistic target of rapamycin complex (mTORC)2 signals to regulate cell survival, nutrient uptake, and metabolism. We report in the present study that mice with TEC-specific ablation of Rictor, a critical and unique adaptor molecule in mTORC2, display thymic atrophy, which accompanies decreased TEC numbers in the medulla. Moreover, generation of multiple T cell lineages, including conventional TCRαβ T cells, regulatory T cells, invariant NKT cells, and TCRγδ T cells, was reduced in TEC-specific Rictor-deficient mice. Our data demonstrate that mTORC2 in TECs is important for normal thymopoiesis and efficient T cell generation.

Duke Scholars

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Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

July 1, 2016

Volume

197

Issue

1

Start / End Page

141 / 150

Location

United States

Related Subject Headings

  • Thymus Gland
  • TOR Serine-Threonine Kinases
  • T-Lymphocytes
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, Antigen, T-Cell, alpha-beta
  • Rapamycin-Insensitive Companion of mTOR Protein
  • Multiprotein Complexes
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
 

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Wang, H.-X., Cheng, J. S., Chu, S., Qiu, Y.-R., & Zhong, X.-P. (2016). mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development. J Immunol, 197(1), 141–150. https://doi.org/10.4049/jimmunol.1502698
Wang, Hong-Xia, Joyce S. Cheng, Shuai Chu, Yu-Rong Qiu, and Xiao-Ping Zhong. “mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development.J Immunol 197, no. 1 (July 1, 2016): 141–50. https://doi.org/10.4049/jimmunol.1502698.
Wang H-X, Cheng JS, Chu S, Qiu Y-R, Zhong X-P. mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development. J Immunol. 2016 Jul 1;197(1):141–50.
Wang, Hong-Xia, et al. “mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development.J Immunol, vol. 197, no. 1, July 2016, pp. 141–50. Pubmed, doi:10.4049/jimmunol.1502698.
Wang H-X, Cheng JS, Chu S, Qiu Y-R, Zhong X-P. mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development. J Immunol. 2016 Jul 1;197(1):141–150.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

July 1, 2016

Volume

197

Issue

1

Start / End Page

141 / 150

Location

United States

Related Subject Headings

  • Thymus Gland
  • TOR Serine-Threonine Kinases
  • T-Lymphocytes
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, Antigen, T-Cell, alpha-beta
  • Rapamycin-Insensitive Companion of mTOR Protein
  • Multiprotein Complexes
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice