Skip to main content
Journal cover image

Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study.

Publication ,  Journal Article
Wang, C; Subashi, E; Liang, X; Yin, F-F; Chang, Z
Published in: Phys Med Biol
July 7, 2016

This study compares the shutter-speed (SS) and the Tofts models as used in assessing therapeutic response in a longitudinal DCE-MRI experiment. Sixteen nu/nu mice with implanted colorectal adenocarcinoma cell line (LS-174T) were randomly assigned into treatment/control groups (n  =  8/group) and received bevacizumab/saline twice weekly (Day1/Day4/Day8). All mice were scanned at one pre- (Day0) and two post-treatment (Day2/Day9) time points using a high spatiotemporal resolution DCE-MRI pulse sequence. The CA extravasation rate constant [Formula: see text] from the Tofts/SS model and the mean intracellular water residence time [Formula: see text] from the SS model were analyzed. A biological subvolume (BV) within the tumor was identified based on the [Formula: see text] intensity distribution, and the SS model parameters within the BV ([Formula: see text] and [Formula: see text]) were analyzed. It is found that [Formula: see text] and [Formula: see text] have a similar spatial distribution in the tumor volume. The Bayesian information criterion results show that the SS model was a better fit for all scans. At Day9, the treatment group had significantly higher tumor mean [Formula: see text] (p  =  0.021), [Formula: see text] (p  =  0.021) and [Formula: see text] (p  = 0.045). When BV from transcytolemmal water exchange analysis was adopted, the treatment group had higher mean [Formula: see text] at both Day2 (p  =  0.038) and Day9 (p  =  0.007). Additionally, at Day9, the treatment group had higher mean [Formula: see text] (p  =  0.045) and higher [Formula: see text] spatial heterogeneity indices (Rényi dimensions) d 1 (p  = 0.010) and d 2 (p  = 0.021). When mean [Formula: see text] and its coefficient of variation (CV) were used to separate treatment/control group samples using supporting vector machine, the accuracy of treatment/control classification was 68.8% at Day2 and 87.5% at Day9; in contrast, the Day2/Day9 accuracy were 62.5%/87.5% using tumor mean [Formula: see text] and its CV and were 50.0%/87.5% using tumor mean [Formula: see text] and its CV, respectively. These results suggest that the SS model parameters outperformed the Tofts model parameters in terms of capturing bevacizumab therapeutic effect in this longitudinal experiment.

Duke Scholars

Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

July 7, 2016

Volume

61

Issue

13

Start / End Page

4763 / 4780

Location

England

Related Subject Headings

  • Water
  • Tumor Burden
  • Treatment Outcome
  • Nuclear Medicine & Medical Imaging
  • Models, Biological
  • Mice
  • Magnetic Resonance Imaging
  • Female
  • Contrast Media
  • Colorectal Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, C., Subashi, E., Liang, X., Yin, F.-F., & Chang, Z. (2016). Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study. Phys Med Biol, 61(13), 4763–4780. https://doi.org/10.1088/0031-9155/61/13/4763
Wang, Chunhao, Ergys Subashi, Xiao Liang, Fang-Fang Yin, and Zheng Chang. “Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study.Phys Med Biol 61, no. 13 (July 7, 2016): 4763–80. https://doi.org/10.1088/0031-9155/61/13/4763.
Wang, Chunhao, et al. “Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study.Phys Med Biol, vol. 61, no. 13, July 2016, pp. 4763–80. Pubmed, doi:10.1088/0031-9155/61/13/4763.
Wang C, Subashi E, Liang X, Yin F-F, Chang Z. Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study. Phys Med Biol. 2016 Jul 7;61(13):4763–4780.
Journal cover image

Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

July 7, 2016

Volume

61

Issue

13

Start / End Page

4763 / 4780

Location

England

Related Subject Headings

  • Water
  • Tumor Burden
  • Treatment Outcome
  • Nuclear Medicine & Medical Imaging
  • Models, Biological
  • Mice
  • Magnetic Resonance Imaging
  • Female
  • Contrast Media
  • Colorectal Neoplasms