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Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine?

Publication ,  Journal Article
Limkakeng, AT; Monte, AA; Kabrhel, C; Puskarich, M; Heitsch, L; Tsalik, EL; Shapiro, NI
Published in: Acad Emerg Med
October 2016

Precision medicine is an emerging approach to disease treatment and prevention that considers variability in patient genes, environment, and lifestyle. However, little has been written about how such research impacts emergency care. Recent advances in analytical techniques have made it possible to characterize patients in a more comprehensive and sophisticated fashion at the molecular level, promising highly individualized diagnosis and treatment. Among these techniques are various systematic molecular phenotyping analyses (e.g., genomics, transcriptomics, proteomics, and metabolomics). Although a number of emergency physicians use such techniques in their research, widespread discussion of these approaches has been lacking in the emergency care literature and many emergency physicians may be unfamiliar with them. In this article, we briefly review the underpinnings of such studies, note how they already impact acute care, discuss areas in which they might soon be applied, and identify challenges in translation to the emergency department (ED). While such techniques hold much promise, it is unclear whether the obstacles to translating their findings to the ED will be overcome in the near future. Such obstacles include validation, cost, turnaround time, user interface, decision support, standardization, and adoption by end-users.

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Published In

Acad Emerg Med

DOI

EISSN

1553-2712

Publication Date

October 2016

Volume

23

Issue

10

Start / End Page

1097 / 1106

Location

United States

Related Subject Headings

  • Precision Medicine
  • Phenotype
  • Metabolomics
  • Male
  • Humans
  • Emergency Service, Hospital
  • Emergency Medicine
  • Emergency & Critical Care Medicine
  • Biomarkers
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Limkakeng, A. T., Monte, A. A., Kabrhel, C., Puskarich, M., Heitsch, L., Tsalik, E. L., & Shapiro, N. I. (2016). Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine? Acad Emerg Med, 23(10), 1097–1106. https://doi.org/10.1111/acem.13027
Limkakeng, Alexander T., Andrew A. Monte, Christopher Kabrhel, Michael Puskarich, Laura Heitsch, Ephraim L. Tsalik, and Nathan I. Shapiro. “Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine?Acad Emerg Med 23, no. 10 (October 2016): 1097–1106. https://doi.org/10.1111/acem.13027.
Limkakeng AT, Monte AA, Kabrhel C, Puskarich M, Heitsch L, Tsalik EL, et al. Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine? Acad Emerg Med. 2016 Oct;23(10):1097–106.
Limkakeng, Alexander T., et al. “Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine?Acad Emerg Med, vol. 23, no. 10, Oct. 2016, pp. 1097–106. Pubmed, doi:10.1111/acem.13027.
Limkakeng AT, Monte AA, Kabrhel C, Puskarich M, Heitsch L, Tsalik EL, Shapiro NI. Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine? Acad Emerg Med. 2016 Oct;23(10):1097–1106.
Journal cover image

Published In

Acad Emerg Med

DOI

EISSN

1553-2712

Publication Date

October 2016

Volume

23

Issue

10

Start / End Page

1097 / 1106

Location

United States

Related Subject Headings

  • Precision Medicine
  • Phenotype
  • Metabolomics
  • Male
  • Humans
  • Emergency Service, Hospital
  • Emergency Medicine
  • Emergency & Critical Care Medicine
  • Biomarkers
  • Adult