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Biopsy and Noninvasive Methods to Assess Progression of Nonalcoholic Fatty Liver Disease.

Publication ,  Journal Article
Bedossa, P; Patel, K
Published in: Gastroenterology
June 2016

Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of histopathologic features, ranging from isolated hepatic steatosis, to steatohepatitis with evidence of hepatocellular injury and fibrosis, to cirrhosis. The diagnosis and determination of NAFLD prognosis requires clinical and histopathologic assessments. Liver biopsy still is regarded as the reference for differentiating steatosis (NAFL) from nonalcoholic steatohepatitis, for staging hepatic fibrosis, and for identifying NAFLD in patients with other chronic liver disease. Standardized grading and staging histologic scoring systems, such as the NAFLD activity score and the steatosis, activity, and fibrosis score, can help guide clinical decisions and assess outcomes of clinical trials. Improved understanding of the pathophysiology of NAFLD and technologic advances have led to algorithms that can be used to assess serum biomarkers and imaging methods that are noninvasive alternatives to biopsy collection and analysis. We review the advantages and limitations of biopsy analysis and noninvasive tests as diagnostic and prognostic tools for patients with NAFLD. We also discuss techniques to improve dynamic histopathology assessment, and emerging blood and imaging biomarkers of fibrogenesis.

Duke Scholars

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Published In

Gastroenterology

DOI

EISSN

1528-0012

Publication Date

June 2016

Volume

150

Issue

8

Start / End Page

1811 / 1822.e4

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Prognosis
  • Non-alcoholic Fatty Liver Disease
  • Liver Cirrhosis
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Disease Progression
  • Biopsy
  • Biomarkers
 

Citation

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Bedossa, P., & Patel, K. (2016). Biopsy and Noninvasive Methods to Assess Progression of Nonalcoholic Fatty Liver Disease. Gastroenterology, 150(8), 1811-1822.e4. https://doi.org/10.1053/j.gastro.2016.03.008
Bedossa, Pierre, and Keyur Patel. “Biopsy and Noninvasive Methods to Assess Progression of Nonalcoholic Fatty Liver Disease.Gastroenterology 150, no. 8 (June 2016): 1811-1822.e4. https://doi.org/10.1053/j.gastro.2016.03.008.
Bedossa P, Patel K. Biopsy and Noninvasive Methods to Assess Progression of Nonalcoholic Fatty Liver Disease. Gastroenterology. 2016 Jun;150(8):1811-1822.e4.
Bedossa, Pierre, and Keyur Patel. “Biopsy and Noninvasive Methods to Assess Progression of Nonalcoholic Fatty Liver Disease.Gastroenterology, vol. 150, no. 8, June 2016, pp. 1811-1822.e4. Pubmed, doi:10.1053/j.gastro.2016.03.008.
Bedossa P, Patel K. Biopsy and Noninvasive Methods to Assess Progression of Nonalcoholic Fatty Liver Disease. Gastroenterology. 2016 Jun;150(8):1811-1822.e4.
Journal cover image

Published In

Gastroenterology

DOI

EISSN

1528-0012

Publication Date

June 2016

Volume

150

Issue

8

Start / End Page

1811 / 1822.e4

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Prognosis
  • Non-alcoholic Fatty Liver Disease
  • Liver Cirrhosis
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Disease Progression
  • Biopsy
  • Biomarkers