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Apixaban to prevent stroke in patients with atrial fibrillation: a review.

Publication ,  Journal Article
Peterson, BE; Al-Khatib, SM; Granger, CB
Published in: Ther Adv Cardiovasc Dis
March 2017

Atrial fibrillation is a common, costly and morbid cardiovascular arrhythmia. Stroke prevention remains the mainstay of treatment for atrial fibrillation, and the recent advent of novel oral anticoagulants with direct factor IIa or factor Xa inhibition has significantly revolutionized this aspect of treatment for atrial fibrillation patients. This review focuses on the tolerability and efficacy of apixaban and tackles the generalizability of the findings with apixaban to broader patient populations than those primarily enrolled in the clinical trials, drawing from the AVERROES and ARISTOTLE trials and their subsequent secondary analyses. Taken together, findings from these trials show that apixaban is superior to warfarin in preventing stroke with a lower risk of major bleeding in the general population of patients with atrial fibrillation as well as in several key high-risk patient subgroups.

Duke Scholars

Published In

Ther Adv Cardiovasc Dis

DOI

EISSN

1753-9455

Publication Date

March 2017

Volume

11

Issue

3

Start / End Page

91 / 104

Location

England

Related Subject Headings

  • Stroke
  • Pyridones
  • Pyrazoles
  • Humans
  • Factor Xa Inhibitors
  • Cardiovascular System & Hematology
  • Atrial Fibrillation
  • Administration, Oral
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Peterson, B. E., Al-Khatib, S. M., & Granger, C. B. (2017). Apixaban to prevent stroke in patients with atrial fibrillation: a review. Ther Adv Cardiovasc Dis, 11(3), 91–104. https://doi.org/10.1177/1753944716652787
Peterson, Benjamin E., Sana M. Al-Khatib, and Christopher B. Granger. “Apixaban to prevent stroke in patients with atrial fibrillation: a review.Ther Adv Cardiovasc Dis 11, no. 3 (March 2017): 91–104. https://doi.org/10.1177/1753944716652787.
Peterson BE, Al-Khatib SM, Granger CB. Apixaban to prevent stroke in patients with atrial fibrillation: a review. Ther Adv Cardiovasc Dis. 2017 Mar;11(3):91–104.
Peterson, Benjamin E., et al. “Apixaban to prevent stroke in patients with atrial fibrillation: a review.Ther Adv Cardiovasc Dis, vol. 11, no. 3, Mar. 2017, pp. 91–104. Pubmed, doi:10.1177/1753944716652787.
Peterson BE, Al-Khatib SM, Granger CB. Apixaban to prevent stroke in patients with atrial fibrillation: a review. Ther Adv Cardiovasc Dis. 2017 Mar;11(3):91–104.
Journal cover image

Published In

Ther Adv Cardiovasc Dis

DOI

EISSN

1753-9455

Publication Date

March 2017

Volume

11

Issue

3

Start / End Page

91 / 104

Location

England

Related Subject Headings

  • Stroke
  • Pyridones
  • Pyrazoles
  • Humans
  • Factor Xa Inhibitors
  • Cardiovascular System & Hematology
  • Atrial Fibrillation
  • Administration, Oral
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology