Skip to main content
Journal cover image

Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats.

Publication ,  Journal Article
Levin, ED; Hall, BJ; Chattopadhyay, A; Slade, S; Wells, C; Rezvani, AH; Rose, JE
Published in: Psychopharmacology (Berl)
August 2016

RATIONALE: Chronic nicotine infusion via transdermal patches has been widely shown to assist with smoking cessation. In particular, transdermal nicotine treatment prior to quitting smoking helps reduce ad libitum smoking and aids cessation Rose et al. (Nicotine Tob Res 11:1067-75, 2009). However, despite this success, the majority of smokers who use transdermal nicotine fail to permanently quit smoking. Additional treatments are needed. Tobacco addiction does not just depend on nicotinic receptor systems; a variety of neural systems are involved, including dopamine, norepinepherine, serotonin, and histamine. OBJECTIVES: Given the involvement of a variety of neural systems in the circuits of addiction, combination therapy may offer improved efficacy for successful smoking cessation beyond single treatments alone. We have found that pyrilamine, an H1 histamine antagonist, significantly decreases nicotine self-administration in rats. METHODS: The current study was conducted to confirm the effect of chronic nicotine infusion on ongoing nicotine self-administration and resumed access after enforced abstinence and to determine the interaction of chronic nicotine with an H1 antagonist treatment. RESULTS: Chronic nicotine infusion via osmotic minipump (2.5 and 5 mg/kg/day for 28 days) significantly reduced nicotine self-administration in a dose-dependent manner. Chronic nicotine infusion also reduced the resumption of nicotine self-administration after enforced abstinence. Chronic pyrilamine infusion (25 mg/kg/day for 14 days) also significantly reduced nicotine self-administration. CONCLUSION: The combination of chronic nicotine and pyrilamine reduced nicotine self-administration to a greater extent than treatment with either drug alone.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Psychopharmacology (Berl)

DOI

EISSN

1432-2072

Publication Date

August 2016

Volume

233

Issue

15-16

Start / End Page

3009 / 3015

Location

Germany

Related Subject Headings

  • Self Administration
  • Rats
  • Pyrilamine
  • Psychiatry
  • Nicotinic Agonists
  • Nicotine
  • Infusions, Subcutaneous
  • Humans
  • Histamine H1 Antagonists
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Levin, E. D., Hall, B. J., Chattopadhyay, A., Slade, S., Wells, C., Rezvani, A. H., & Rose, J. E. (2016). Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats. Psychopharmacology (Berl), 233(15–16), 3009–3015. https://doi.org/10.1007/s00213-016-4347-1
Levin, Edward D., Brandon J. Hall, Autri Chattopadhyay, Susan Slade, Corinne Wells, Amir H. Rezvani, and Jed E. Rose. “Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats.Psychopharmacology (Berl) 233, no. 15–16 (August 2016): 3009–15. https://doi.org/10.1007/s00213-016-4347-1.
Levin ED, Hall BJ, Chattopadhyay A, Slade S, Wells C, Rezvani AH, et al. Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats. Psychopharmacology (Berl). 2016 Aug;233(15–16):3009–15.
Levin, Edward D., et al. “Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats.Psychopharmacology (Berl), vol. 233, no. 15–16, Aug. 2016, pp. 3009–15. Pubmed, doi:10.1007/s00213-016-4347-1.
Levin ED, Hall BJ, Chattopadhyay A, Slade S, Wells C, Rezvani AH, Rose JE. Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats. Psychopharmacology (Berl). 2016 Aug;233(15–16):3009–3015.
Journal cover image

Published In

Psychopharmacology (Berl)

DOI

EISSN

1432-2072

Publication Date

August 2016

Volume

233

Issue

15-16

Start / End Page

3009 / 3015

Location

Germany

Related Subject Headings

  • Self Administration
  • Rats
  • Pyrilamine
  • Psychiatry
  • Nicotinic Agonists
  • Nicotine
  • Infusions, Subcutaneous
  • Humans
  • Histamine H1 Antagonists
  • Female