Skip to main content
Journal cover image

Nonvitamin K Anticoagulant Agents in Patients With Advanced Chronic Kidney Disease or on Dialysis With AF.

Publication ,  Journal Article
Chan, KE; Giugliano, RP; Patel, MR; Abramson, S; Jardine, M; Zhao, S; Perkovic, V; Maddux, FW; Piccini, JP
Published in: J Am Coll Cardiol
June 21, 2016

Nonvitamin K-dependent oral anticoagulant agents (NOACs) are currently recommended for patients with atrial fibrillation at risk for stroke. As a group, NOACs significantly reduce stroke, intracranial hemorrhage, and mortality, with lower to similar major bleeding rates compared with warfarin. All NOACs are dependent on the kidney for elimination, such that patients with creatinine clearance <25 ml/min were excluded from all the pivotal phase 3 NOAC trials. It therefore remains unclear how or if NOACs should be prescribed to patients with advanced chronic kidney disease and those on dialysis. The authors review the current pharmacokinetic, observational, and prospective data on NOACs in patients with advanced chronic kidney disease (creatinine clearance <30 ml/min) and those on dialysis. The authors frame the evidence in terms of risk versus benefit to bring greater clarity to NOAC-related major bleeding and efficacy at preventing stroke specifically in patients with creatinine clearance <30 ml/min.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

June 21, 2016

Volume

67

Issue

24

Start / End Page

2888 / 2899

Location

United States

Related Subject Headings

  • Warfarin
  • Thiazoles
  • Stroke
  • Rivaroxaban
  • Renal Insufficiency, Chronic
  • Renal Dialysis
  • Pyridones
  • Pyridines
  • Pyrazoles
  • Kidney Failure, Chronic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chan, K. E., Giugliano, R. P., Patel, M. R., Abramson, S., Jardine, M., Zhao, S., … Piccini, J. P. (2016). Nonvitamin K Anticoagulant Agents in Patients With Advanced Chronic Kidney Disease or on Dialysis With AF. J Am Coll Cardiol, 67(24), 2888–2899. https://doi.org/10.1016/j.jacc.2016.02.082
Chan, Kevin E., Robert P. Giugliano, Manesh R. Patel, Stuart Abramson, Meg Jardine, Sophia Zhao, Vlado Perkovic, Franklin W. Maddux, and Jonathan P. Piccini. “Nonvitamin K Anticoagulant Agents in Patients With Advanced Chronic Kidney Disease or on Dialysis With AF.J Am Coll Cardiol 67, no. 24 (June 21, 2016): 2888–99. https://doi.org/10.1016/j.jacc.2016.02.082.
Chan KE, Giugliano RP, Patel MR, Abramson S, Jardine M, Zhao S, et al. Nonvitamin K Anticoagulant Agents in Patients With Advanced Chronic Kidney Disease or on Dialysis With AF. J Am Coll Cardiol. 2016 Jun 21;67(24):2888–99.
Chan, Kevin E., et al. “Nonvitamin K Anticoagulant Agents in Patients With Advanced Chronic Kidney Disease or on Dialysis With AF.J Am Coll Cardiol, vol. 67, no. 24, June 2016, pp. 2888–99. Pubmed, doi:10.1016/j.jacc.2016.02.082.
Chan KE, Giugliano RP, Patel MR, Abramson S, Jardine M, Zhao S, Perkovic V, Maddux FW, Piccini JP. Nonvitamin K Anticoagulant Agents in Patients With Advanced Chronic Kidney Disease or on Dialysis With AF. J Am Coll Cardiol. 2016 Jun 21;67(24):2888–2899.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

June 21, 2016

Volume

67

Issue

24

Start / End Page

2888 / 2899

Location

United States

Related Subject Headings

  • Warfarin
  • Thiazoles
  • Stroke
  • Rivaroxaban
  • Renal Insufficiency, Chronic
  • Renal Dialysis
  • Pyridones
  • Pyridines
  • Pyrazoles
  • Kidney Failure, Chronic