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Influence of Kidney Function on Blood Pressure Response to Lifestyle Modifications: Secondary Analysis From the Exercise and Nutritional Interventions for Cardiovascular Health (ENCORE) Trial.

Publication ,  Journal Article
Tyson, CC; Smith, PJ; Sherwood, A; Mabe, S; Hinderliter, AL; Blumenthal, JA
Published in: J Clin Hypertens (Greenwich)
December 2016

The kidney is an important regulator of blood pressure (BP). To determine whether BP response to lifestyle modification varies across normal ranges of kidney function, the authors examined the moderating role of estimated glomerular filtration rate (eGFR) on clinic and ambulatory systolic BP (SBP) response in overweight and obese adults with unmedicated high BP. Among 144 participants of the Exercise and Nutritional Interventions for Cardiovascular Health (ENCORE) trial, mean age was 52.0±9.6 years and median eGFR was 89.1 (53-146) mL/min/1.73m2 . After multivariable regression, the interaction between eGFR and weight loss was significant for clinic (P=.023) and ambulatory SBP (P=.041). Similarly, the interaction between eGFR and improved fitness was significant for clinic (P=.041) and ambulatory SBP (P=.044). The relationship between reduced dietary sodium and SBP was not moderated by eGFR. SBP findings were inconsistent for adherence to the Dietary Approaches to Stop Hypertension (DASH) diet. These findings suggest that the effects of lifestyle modifications on SBP may be influenced by eGFR, even when kidney function is preserved.

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Published In

J Clin Hypertens (Greenwich)

DOI

EISSN

1751-7176

Publication Date

December 2016

Volume

18

Issue

12

Start / End Page

1260 / 1267

Location

United States

Related Subject Headings

  • Weight Reduction Programs
  • Physical Conditioning, Human
  • Overweight
  • Obesity
  • Middle Aged
  • Male
  • Life Style
  • Kidney
  • Humans
  • Healthy Lifestyle
 

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Tyson, C. C., Smith, P. J., Sherwood, A., Mabe, S., Hinderliter, A. L., & Blumenthal, J. A. (2016). Influence of Kidney Function on Blood Pressure Response to Lifestyle Modifications: Secondary Analysis From the Exercise and Nutritional Interventions for Cardiovascular Health (ENCORE) Trial. J Clin Hypertens (Greenwich), 18(12), 1260–1267. https://doi.org/10.1111/jch.12853
Tyson, Crystal C., Patrick J. Smith, Andrew Sherwood, Stephanie Mabe, Alan L. Hinderliter, and James A. Blumenthal. “Influence of Kidney Function on Blood Pressure Response to Lifestyle Modifications: Secondary Analysis From the Exercise and Nutritional Interventions for Cardiovascular Health (ENCORE) Trial.J Clin Hypertens (Greenwich) 18, no. 12 (December 2016): 1260–67. https://doi.org/10.1111/jch.12853.
Tyson, Crystal C., et al. “Influence of Kidney Function on Blood Pressure Response to Lifestyle Modifications: Secondary Analysis From the Exercise and Nutritional Interventions for Cardiovascular Health (ENCORE) Trial.J Clin Hypertens (Greenwich), vol. 18, no. 12, Dec. 2016, pp. 1260–67. Pubmed, doi:10.1111/jch.12853.
Tyson CC, Smith PJ, Sherwood A, Mabe S, Hinderliter AL, Blumenthal JA. Influence of Kidney Function on Blood Pressure Response to Lifestyle Modifications: Secondary Analysis From the Exercise and Nutritional Interventions for Cardiovascular Health (ENCORE) Trial. J Clin Hypertens (Greenwich). 2016 Dec;18(12):1260–1267.
Journal cover image

Published In

J Clin Hypertens (Greenwich)

DOI

EISSN

1751-7176

Publication Date

December 2016

Volume

18

Issue

12

Start / End Page

1260 / 1267

Location

United States

Related Subject Headings

  • Weight Reduction Programs
  • Physical Conditioning, Human
  • Overweight
  • Obesity
  • Middle Aged
  • Male
  • Life Style
  • Kidney
  • Humans
  • Healthy Lifestyle