Insulin or glucagon choleresis in the isolated perfused guinea pig liver.
Insulin and glucagon choleresis was studied in an in situ, isolated perfused guinea pig liver system. Glucagon caused a small, significant increase in bile salt independent flow (1.83 +/- 0.19 to 2.02 +/- 0.23 microliter g-1 min-1), and dose-related increments over 2-16 micrograms were observed. Insulin alone had no choleretic effect. However, the combination of insulin and glucagon caused a response (1.89 +/- 0.15 to 2.42 +/- 0.19) greater than glucagon alone, and insulin stimulated choleresis when glucagon was present in substimulatory amounts. These observations demonstrate direct effects of glucagon and insulin upon the bile secretory apparatus. Glucagon directly stimulates choleresis, while insulin acts more subtly by potentiation with glucagon.
Duke Scholars
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Perfusion
- Liver
- Insulin
- Hyperglycemia
- Guinea Pigs
- Glucagon
- Dose-Response Relationship, Drug
- Cholagogues and Choleretics
- Biochemistry & Molecular Biology
- Bile Acids and Salts
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Perfusion
- Liver
- Insulin
- Hyperglycemia
- Guinea Pigs
- Glucagon
- Dose-Response Relationship, Drug
- Cholagogues and Choleretics
- Biochemistry & Molecular Biology
- Bile Acids and Salts