Effect of glucagon and insulin on biliary lipid secretion

Because previous studies have suggested that glucagon and insulin stimulate canalicular choleresis, it seemed important to investigate their lipid secretory effects. Dogs were prepared with cholecystectomy, ligation of the lesser pancreatic duct, and insertion of gastric and duodenal cannulas. During experiments, the common bile duct was cannulated through the duodenal fistula. After stabilization of bile flow by intravenous infusion of sodium taurocholate, each dog received IV infusion of 2 μg kg-1hr-1 glucagon (G), O.5 u kg-1hr-1 insulin (I), glucagon plus insulin (G&I), or 0.9% sodium chloride (C). The experiments were performed with 250 mg/hr and 500 mg/hr bile salt infusion rates.

Duke Scholars

Author William Clark Meyers Surgery