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Somatostatin-induced cholestasis can be independent of portal blood flow.

Publication ,  Journal Article
Kortz, WJ; Meyers, WC; Schirmer, BD; Jones, RS
Published in: Surgery
May 1983

Short-term experiments were performed on adult mongrel dogs (15 to 25 kg) anesthetized with sodium pentobarbital. The operative procedure included cholecystectomy, side-to-side mesocaval shunt with ligation of the portal vein, and cannulation of the common bile duct. Intravenous sodium taurocholate (500 mg/hr) was administered to prevent depletion of bile salts. Somatostatin (125 micrograms over 30 minutes) was given to six dogs after 2 hours of bile salt infusion, while six additional dogs received saline to serve as control. Bile flow decreased significantly during administration of somatostatin (206 +/- 28 to 150 +/- 21 microliters kg-1 15 min-1, P less than 0.001) and was unchanged during administration of saline (216 +/- 45 to 216 +/- 46 microliters kg-1 15 min-1). This decrease persisted for 1/2 hour after cessation of the somatostatin infusion. Bile salt outputs were similar for both groups throughout the experiment. The data demonstrate that somatostatin-induced cholestasis can be independent of portal blood flow.

Duke Scholars

Published In

Surgery

ISSN

0039-6060

Publication Date

May 1983

Volume

93

Issue

5

Start / End Page

649 / 652

Location

United States

Related Subject Headings

  • Surgery
  • Somatostatin
  • Portal System
  • Liver Circulation
  • Dogs
  • Cholestasis
  • Bile Acids and Salts
  • Bile
  • Animals
  • 1103 Clinical Sciences
 

Citation

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Kortz, W. J., Meyers, W. C., Schirmer, B. D., & Jones, R. S. (1983). Somatostatin-induced cholestasis can be independent of portal blood flow. Surgery, 93(5), 649–652.
Kortz, W. J., W. C. Meyers, B. D. Schirmer, and R. S. Jones. “Somatostatin-induced cholestasis can be independent of portal blood flow.Surgery 93, no. 5 (May 1983): 649–52.
Kortz WJ, Meyers WC, Schirmer BD, Jones RS. Somatostatin-induced cholestasis can be independent of portal blood flow. Surgery. 1983 May;93(5):649–52.
Kortz, W. J., et al. “Somatostatin-induced cholestasis can be independent of portal blood flow.Surgery, vol. 93, no. 5, May 1983, pp. 649–52.
Kortz WJ, Meyers WC, Schirmer BD, Jones RS. Somatostatin-induced cholestasis can be independent of portal blood flow. Surgery. 1983 May;93(5):649–652.
Journal cover image

Published In

Surgery

ISSN

0039-6060

Publication Date

May 1983

Volume

93

Issue

5

Start / End Page

649 / 652

Location

United States

Related Subject Headings

  • Surgery
  • Somatostatin
  • Portal System
  • Liver Circulation
  • Dogs
  • Cholestasis
  • Bile Acids and Salts
  • Bile
  • Animals
  • 1103 Clinical Sciences