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Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders.

Publication ,  Journal Article
Georgopoulos, AP; Karageorgiou, E; Leuthold, AC; Lewis, SM; Lynch, JK; Alonso, AA; Aslam, Z; Carpenter, AF; Georgopoulos, A; Hemmy, LS ...
Published in: J Neural Eng
December 2007

We report on a test to assess the dynamic brain function at high temporal resolution using magnetoencephalography (MEG). The essence of the test is the measurement of the dynamic synchronous neural interactions, an essential aspect of the brain function. MEG signals were recorded from 248 axial gradiometers while 142 human subjects fixated a spot of light for 45-60 s. After fitting an autoregressive integrative moving average (ARIMA) model and taking the stationary residuals, all pairwise, zero-lag, partial cross-correlations (PCC(ij)(0)) and their z-transforms (z(ij)(0)) between i and j sensors were calculated, providing estimates of the strength and sign (positive, negative) of direct synchronous coupling at 1 ms temporal resolution. We found that subsets of z(ij)(0) successfully classified individual subjects to their respective groups (multiple sclerosis, Alzheimer's disease, schizophrenia, Sjögren's syndrome, chronic alcoholism, facial pain, healthy controls) and gave excellent external cross-validation results.

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Published In

J Neural Eng

DOI

ISSN

1741-2560

Publication Date

December 2007

Volume

4

Issue

4

Start / End Page

349 / 355

Location

England

Related Subject Headings

  • Nerve Net
  • Middle Aged
  • Male
  • Magnetoencephalography
  • Humans
  • Female
  • Diagnosis, Computer-Assisted
  • Child
  • Brain Diseases
  • Brain
 

Citation

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Georgopoulos, A. P., Karageorgiou, E., Leuthold, A. C., Lewis, S. M., Lynch, J. K., Alonso, A. A., … Westermeyer, J. J. (2007). Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders. J Neural Eng, 4(4), 349–355. https://doi.org/10.1088/1741-2560/4/4/001
Georgopoulos, Apostolos P., Elissaios Karageorgiou, Arthur C. Leuthold, Scott M. Lewis, Joshua K. Lynch, Aurelio A. Alonso, Zaheer Aslam, et al. “Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders.J Neural Eng 4, no. 4 (December 2007): 349–55. https://doi.org/10.1088/1741-2560/4/4/001.
Georgopoulos AP, Karageorgiou E, Leuthold AC, Lewis SM, Lynch JK, Alonso AA, et al. Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders. J Neural Eng. 2007 Dec;4(4):349–55.
Georgopoulos, Apostolos P., et al. “Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders.J Neural Eng, vol. 4, no. 4, Dec. 2007, pp. 349–55. Pubmed, doi:10.1088/1741-2560/4/4/001.
Georgopoulos AP, Karageorgiou E, Leuthold AC, Lewis SM, Lynch JK, Alonso AA, Aslam Z, Carpenter AF, Georgopoulos A, Hemmy LS, Koutlas IG, Langheim FJP, McCarten JR, McPherson SE, Pardo JV, Pardo PJ, Parry GJ, Rottunda SJ, Segal BM, Sponheim SR, Stanwyck JJ, Stephane M, Westermeyer JJ. Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders. J Neural Eng. 2007 Dec;4(4):349–355.
Journal cover image

Published In

J Neural Eng

DOI

ISSN

1741-2560

Publication Date

December 2007

Volume

4

Issue

4

Start / End Page

349 / 355

Location

England

Related Subject Headings

  • Nerve Net
  • Middle Aged
  • Male
  • Magnetoencephalography
  • Humans
  • Female
  • Diagnosis, Computer-Assisted
  • Child
  • Brain Diseases
  • Brain