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LOC387715/HTRA1 and complement factor H variants in patients with age-related macular degeneration seen at the mayo clinic.

Publication ,  Journal Article
Pulido, JS; Peterson, LM; Mutapcic, L; Bryant, S; Highsmith, WE
Published in: Ophthalmic Genet
December 2007

PURPOSE: To confirm association of the complement factor H allelic variant (CFH Y402H) and the LOC387715/HTRA1 (LOC387715 A69S) risk alleles with age-related macular degeneration (AMD). STUDY POPULATION: Study of 89 Caucasian patients with neovascular (exudative) AMD and 232 Caucasian controls. METHODS: The Y402H variant of CFH gene and A69S variant of LOC387715/HTRA1 gene locus were examined. RESULTS: For CFH, the odds ratio for the homozygous variant was 4.97 (CI 2.52 to 9.79). For LOC387715/HTRA1 the odds ratio for the homozygous risk variant was 7.75 (CI 3.46 to 17.35). The odds ratio for heterozygous carriers was 3.35 (CI 1.91 to 5.90).

Duke Scholars

Published In

Ophthalmic Genet

DOI

ISSN

1381-6810

Publication Date

December 2007

Volume

28

Issue

4

Start / End Page

203 / 207

Location

England

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Polymerase Chain Reaction
  • Ophthalmology & Optometry
  • Minnesota
  • Macular Degeneration
  • Humans
  • Genetic Predisposition to Disease
  • DNA Primers
  • Complement Factor H
  • Base Sequence
 

Citation

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Pulido, J. S., Peterson, L. M., Mutapcic, L., Bryant, S., & Highsmith, W. E. (2007). LOC387715/HTRA1 and complement factor H variants in patients with age-related macular degeneration seen at the mayo clinic. Ophthalmic Genet, 28(4), 203–207. https://doi.org/10.1080/13816810701649617
Pulido, Jose S., Lisa M. Peterson, Lejla Mutapcic, Sandra Bryant, and W Edward Highsmith. “LOC387715/HTRA1 and complement factor H variants in patients with age-related macular degeneration seen at the mayo clinic.Ophthalmic Genet 28, no. 4 (December 2007): 203–7. https://doi.org/10.1080/13816810701649617.
Pulido JS, Peterson LM, Mutapcic L, Bryant S, Highsmith WE. LOC387715/HTRA1 and complement factor H variants in patients with age-related macular degeneration seen at the mayo clinic. Ophthalmic Genet. 2007 Dec;28(4):203–7.
Pulido, Jose S., et al. “LOC387715/HTRA1 and complement factor H variants in patients with age-related macular degeneration seen at the mayo clinic.Ophthalmic Genet, vol. 28, no. 4, Dec. 2007, pp. 203–07. Pubmed, doi:10.1080/13816810701649617.
Pulido JS, Peterson LM, Mutapcic L, Bryant S, Highsmith WE. LOC387715/HTRA1 and complement factor H variants in patients with age-related macular degeneration seen at the mayo clinic. Ophthalmic Genet. 2007 Dec;28(4):203–207.
Journal cover image

Published In

Ophthalmic Genet

DOI

ISSN

1381-6810

Publication Date

December 2007

Volume

28

Issue

4

Start / End Page

203 / 207

Location

England

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Polymerase Chain Reaction
  • Ophthalmology & Optometry
  • Minnesota
  • Macular Degeneration
  • Humans
  • Genetic Predisposition to Disease
  • DNA Primers
  • Complement Factor H
  • Base Sequence