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Serum creatinine as marker of kidney function in South Asians: a study of reduced GFR in adults in Pakistan.

Publication ,  Journal Article
Jafar, TH; Schmid, CH; Levey, AS
Published in: Journal of the American Society of Nephrology : JASN
May 2005

Migrant populations of South Asian origin have a higher risk for chronic kidney disease than the native whites. Several formulas have been developed to estimate kidney function from serum creatinine concentration. However, none of these has been validated in the South Asian population, which generally has different muscle mass composition than whites. A population-based cross-sectional study was performed on 262 individuals who were aged > or = 40 yr in Karachi, Pakistan. Reduced GFR was defined as creatinine clearance (Ccr) measured in 24-h urine collection of <60 ml/min per 1.73 m2. Creatinine excretion was compared with age- and gender-matched white individuals by comparison of observed versus expected results on the basis of a formula using t test. The agreement among Cockcroft Gault (CG) Ccr and Modification of Diet in Renal Disease (MDRD) Study GFR equations was assessed by regression analyses, and the degree of accuracy of estimated versus measured GFR was determined. Mean (95% confidence interval) creatinine excretion was 1.7 (1.0 to 2.4) mg/kg per d lower than expected for age- and gender-matched white individuals (P < 0.001). The coefficient of determination for measured Ccr on the logarithmic scale was 66.7 and 55.6% for the CG and MDRD Study equations, respectively. The proportion of estimates within 20, 30, and 50% of measured Ccr values was 47.7 versus 32.8% (P < 0.001), 64.9 versus 49.6% (P < 0.001), and 79.4 versus 72.9 (P = 0.07) for CG versus MDRD Study equations, respectively. Lower mean creatinine excretion in these individuals may explain, in part, suboptimal agreement between estimated versus measured GFR. Inclusion of terms for ethnic and racial groups other than white and black might improve the performance of GFR estimating equations.

Duke Scholars

Published In

Journal of the American Society of Nephrology : JASN

DOI

EISSN

1533-3450

ISSN

1046-6673

Publication Date

May 2005

Volume

16

Issue

5

Start / End Page

1413 / 1419

Related Subject Headings

  • Urology & Nephrology
  • Sensitivity and Specificity
  • ROC Curve
  • Prevalence
  • Predictive Value of Tests
  • Pakistan
  • Middle Aged
  • Male
  • Kidney Diseases
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Jafar, T. H., Schmid, C. H., & Levey, A. S. (2005). Serum creatinine as marker of kidney function in South Asians: a study of reduced GFR in adults in Pakistan. Journal of the American Society of Nephrology : JASN, 16(5), 1413–1419. https://doi.org/10.1681/asn.2004121100
Jafar, Tazeen H., Christopher H. Schmid, and Andrew S. Levey. “Serum creatinine as marker of kidney function in South Asians: a study of reduced GFR in adults in Pakistan.Journal of the American Society of Nephrology : JASN 16, no. 5 (May 2005): 1413–19. https://doi.org/10.1681/asn.2004121100.
Jafar TH, Schmid CH, Levey AS. Serum creatinine as marker of kidney function in South Asians: a study of reduced GFR in adults in Pakistan. Journal of the American Society of Nephrology : JASN. 2005 May;16(5):1413–9.
Jafar, Tazeen H., et al. “Serum creatinine as marker of kidney function in South Asians: a study of reduced GFR in adults in Pakistan.Journal of the American Society of Nephrology : JASN, vol. 16, no. 5, May 2005, pp. 1413–19. Epmc, doi:10.1681/asn.2004121100.
Jafar TH, Schmid CH, Levey AS. Serum creatinine as marker of kidney function in South Asians: a study of reduced GFR in adults in Pakistan. Journal of the American Society of Nephrology : JASN. 2005 May;16(5):1413–1419.

Published In

Journal of the American Society of Nephrology : JASN

DOI

EISSN

1533-3450

ISSN

1046-6673

Publication Date

May 2005

Volume

16

Issue

5

Start / End Page

1413 / 1419

Related Subject Headings

  • Urology & Nephrology
  • Sensitivity and Specificity
  • ROC Curve
  • Prevalence
  • Predictive Value of Tests
  • Pakistan
  • Middle Aged
  • Male
  • Kidney Diseases
  • Humans