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Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein.

Publication ,  Journal Article
Huang, JT; Schneider, RJ
Published in: Cell
April 19, 1991

Adenovirus (Ad) infection results in a marked inhibition of cellular protein synthesis that initiates during the late phase of the viral infectious cycle. We show that the mechanism used for suppression of cellular protein synthesis during cell cycle progression is exploited by Ad to repress host and enhance late viral mRNA translation. Discrimination between cellular and late Ad mRNAs and inhibition of host protein synthesis are shown to involve viral-mediated underphosphorylation of cap-binding protein (CBP) and subsequent inactivation of CBP complex, a large enzymatic complex required for cap-dependent mRNA translation. Late Ad mRNAs, like those of poliovirus, possess the unique ability to translate independent of a normal cap recognition process and do not require the activity of CBP complex. Inhibition of cellular translation by these two viruses is quite similar, except that whereas CBP complex is proteolytically degraded by poliovirus, it is functionally inactivated by Ad.

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Published In

Cell

DOI

ISSN

0092-8674

Publication Date

April 19, 1991

Volume

65

Issue

2

Start / End Page

271 / 280

Location

United States

Related Subject Headings

  • RNA, Messenger
  • RNA Caps
  • RNA Cap-Binding Proteins
  • Protein Biosynthesis
  • Poliovirus
  • Phosphorylation
  • Phosphates
  • Peptide Initiation Factors
  • Models, Genetic
  • Methionine
 

Citation

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Huang, J. T., & Schneider, R. J. (1991). Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein. Cell, 65(2), 271–280. https://doi.org/10.1016/0092-8674(91)90161-q
Huang, J. T., and R. J. Schneider. “Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein.Cell 65, no. 2 (April 19, 1991): 271–80. https://doi.org/10.1016/0092-8674(91)90161-q.
Huang, J. T., and R. J. Schneider. “Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein.Cell, vol. 65, no. 2, Apr. 1991, pp. 271–80. Pubmed, doi:10.1016/0092-8674(91)90161-q.
Journal cover image

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

April 19, 1991

Volume

65

Issue

2

Start / End Page

271 / 280

Location

United States

Related Subject Headings

  • RNA, Messenger
  • RNA Caps
  • RNA Cap-Binding Proteins
  • Protein Biosynthesis
  • Poliovirus
  • Phosphorylation
  • Phosphates
  • Peptide Initiation Factors
  • Models, Genetic
  • Methionine