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Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats.

Publication ,  Journal Article
Kan, MH; Yang, T; Fu, HQ; Fan, L; Wu, Y; Terrando, N; Wang, T-L
Published in: Front Aging Neurosci
2016

Systemic inflammation, for example as a result of infection, often contributes to long-term complications. Neuroinflammation and cognitive decline are key hallmarks of several neurological conditions, including advance age. The contribution of systemic inflammation to the central nervous system (CNS) remains not fully understood. Using a model of peripheral endotoxemia with lipopolysaccharide (LPS) we investigated the role of nuclear factor-κB (NF-κB) activity in mediating long-term neuroinflammation and cognitive dysfunction in aged rats. Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-κB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-α and interleukin-1β (IL-1β) and CNS markers after LPS exposure in aged rats. In the hippocampus, PDTC not only reduced neuroinflammation by modulating canonical NF-κB activity but also affected IL-1β expression in astrocytes. Parallel effects were observed on behavior and postsynaptic density-95 (PSD95), a marker of synaptic function. Taken together these changes improved acute and long-term cognitive function in aged rats after LPS exposure.

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Published In

Front Aging Neurosci

DOI

ISSN

1663-4365

Publication Date

2016

Volume

8

Start / End Page

175

Location

Switzerland

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
  • 0601 Biochemistry and Cell Biology
 

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Kan, M. H., Yang, T., Fu, H. Q., Fan, L., Wu, Y., Terrando, N., & Wang, T.-L. (2016). Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats. Front Aging Neurosci, 8, 175. https://doi.org/10.3389/fnagi.2016.00175
Kan, Min Hui, Ting Yang, Hui Qun Fu, Long Fan, Yan Wu, Niccolò Terrando, and Tian-Long Wang. “Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats.Front Aging Neurosci 8 (2016): 175. https://doi.org/10.3389/fnagi.2016.00175.
Kan MH, Yang T, Fu HQ, Fan L, Wu Y, Terrando N, et al. Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats. Front Aging Neurosci. 2016;8:175.
Kan, Min Hui, et al. “Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats.Front Aging Neurosci, vol. 8, 2016, p. 175. Pubmed, doi:10.3389/fnagi.2016.00175.
Kan MH, Yang T, Fu HQ, Fan L, Wu Y, Terrando N, Wang T-L. Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats. Front Aging Neurosci. 2016;8:175.

Published In

Front Aging Neurosci

DOI

ISSN

1663-4365

Publication Date

2016

Volume

8

Start / End Page

175

Location

Switzerland

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
  • 0601 Biochemistry and Cell Biology