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Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer.

Publication ,  Journal Article
Wu, C; Zhang, L; Bourne, PA; Reeder, JE; di Sant'Agnese, PA; Yao, JL; Na, Y; Huang, J
Published in: Prostate
August 1, 2006

BACKGROUND: Prostate cancer (PC) contains a minor component of neuroendocrine (NE) cells that may stimulate androgen-independent growth of the tumor. The mechanism of neuroendocrine differentiation remains unknown. METHODS: The expression of PTP1B, a protein tyrosine phosphatase, was studied in LNCaP cells induced to show neuroendocrine phenotype by androgen withdrawal. Wild-type PTP1B and its dominant-negative mutant were transfected into LNCaP cells to study their effects on neuroendocrine differentiation. In vivo expression of PTP1B in human prostate cancer was studied by immunohistochemistry. RESULTS: Androgen withdrawal of LNCaP cells led to increased expression of PTP1B with a corresponding increase in its tyrosine phosphatase activity. Overexpression of PTP1B in LNCaP cells led to neuroendocrine differentiation while expression of its dominant-negative mutant inhibited neuroendocrine differentiation. Immunohistochemical study showed that PTP1B was exclusively expressed in neuroendocrine cells of human prostate cancer tissue. CONCLUSION: Our findings suggest that PTP1B plays an important role in neuroendocrine differentiation, and therefore, may possibly be involved in the progression of prostate cancer.

Duke Scholars

Published In

Prostate

DOI

ISSN

0270-4137

Publication Date

August 1, 2006

Volume

66

Issue

11

Start / End Page

1125 / 1135

Location

United States

Related Subject Headings

  • Transfection
  • Reverse Transcriptase Polymerase Chain Reaction
  • Protein Tyrosine Phosphatases
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Neurosecretory Systems
  • Male
  • Immunohistochemistry
  • Humans
 

Citation

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Wu, C., Zhang, L., Bourne, P. A., Reeder, J. E., di Sant’Agnese, P. A., Yao, J. L., … Huang, J. (2006). Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer. Prostate, 66(11), 1125–1135. https://doi.org/10.1002/pros.20412
Wu, Chengyu, Li Zhang, Patricia A. Bourne, Jay E. Reeder, P Anthony di Sant’Agnese, Jorge L. Yao, Yanqun Na, and Jiaoti Huang. “Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer.Prostate 66, no. 11 (August 1, 2006): 1125–35. https://doi.org/10.1002/pros.20412.
Wu C, Zhang L, Bourne PA, Reeder JE, di Sant’Agnese PA, Yao JL, et al. Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer. Prostate. 2006 Aug 1;66(11):1125–35.
Wu, Chengyu, et al. “Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer.Prostate, vol. 66, no. 11, Aug. 2006, pp. 1125–35. Pubmed, doi:10.1002/pros.20412.
Wu C, Zhang L, Bourne PA, Reeder JE, di Sant’Agnese PA, Yao JL, Na Y, Huang J. Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer. Prostate. 2006 Aug 1;66(11):1125–1135.
Journal cover image

Published In

Prostate

DOI

ISSN

0270-4137

Publication Date

August 1, 2006

Volume

66

Issue

11

Start / End Page

1125 / 1135

Location

United States

Related Subject Headings

  • Transfection
  • Reverse Transcriptase Polymerase Chain Reaction
  • Protein Tyrosine Phosphatases
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Neurosecretory Systems
  • Male
  • Immunohistochemistry
  • Humans