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Immunohistochemical characterization of neuroendocrine cells in prostate cancer.

Publication ,  Journal Article
Huang, J; Yao, JL; di Sant'Agnese, PA; Yang, Q; Bourne, PA; Na, Y
Published in: Prostate
September 15, 2006

BACKGROUND: Neuroendocrine (NE) cells increase in high grade/stage prostate cancer (PC) and may contribute to androgen-independent cancer. Their immunohistochemical phenotype has not been studied in detail and conflicting results have been reported. METHODS: PC tissue was stained immunohistochemically for luminal secretory cell-associated cytokeratin, basal cell markers, ki-67, androgen receptor (AR), PSA, prostate acid phosphatase (PAP), and alpha-methylacyl coenzyme A racemase (AMACR). RESULTS: The NE cells are positive for AE1/AE3, Cam 5.2, and negative for basal cell markers. They are negative for AR, PSA, and Ki-67 but positive for PAP. The benign NE cells are negative for AMACR while the malignant NE cells are positive for AMACR. CONCLUSIONS: NE cells of PC constitute a unique subset of cancer cells, which have a unique immunohistochemical profile. They do not express AR, consistent with their resistance to hormonal therapy. They are post-mitotic cells but are malignant and part of the tumor.

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Published In

Prostate

DOI

ISSN

0270-4137

Publication Date

September 15, 2006

Volume

66

Issue

13

Start / End Page

1399 / 1406

Location

United States

Related Subject Headings

  • Receptors, Androgen
  • Racemases and Epimerases
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Phenotype
  • Oncology & Carcinogenesis
  • Neuroendocrine Tumors
  • Male
  • Ki-67 Antigen
  • Keratins
 

Citation

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Huang, J., Yao, J. L., di Sant’Agnese, P. A., Yang, Q., Bourne, P. A., & Na, Y. (2006). Immunohistochemical characterization of neuroendocrine cells in prostate cancer. Prostate, 66(13), 1399–1406. https://doi.org/10.1002/pros.20434
Huang, Jiaoti, Jorge L. Yao, P Anthony di Sant’Agnese, Qi Yang, Patricia A. Bourne, and Yanqun Na. “Immunohistochemical characterization of neuroendocrine cells in prostate cancer.Prostate 66, no. 13 (September 15, 2006): 1399–1406. https://doi.org/10.1002/pros.20434.
Huang J, Yao JL, di Sant’Agnese PA, Yang Q, Bourne PA, Na Y. Immunohistochemical characterization of neuroendocrine cells in prostate cancer. Prostate. 2006 Sep 15;66(13):1399–406.
Huang, Jiaoti, et al. “Immunohistochemical characterization of neuroendocrine cells in prostate cancer.Prostate, vol. 66, no. 13, Sept. 2006, pp. 1399–406. Pubmed, doi:10.1002/pros.20434.
Huang J, Yao JL, di Sant’Agnese PA, Yang Q, Bourne PA, Na Y. Immunohistochemical characterization of neuroendocrine cells in prostate cancer. Prostate. 2006 Sep 15;66(13):1399–1406.
Journal cover image

Published In

Prostate

DOI

ISSN

0270-4137

Publication Date

September 15, 2006

Volume

66

Issue

13

Start / End Page

1399 / 1406

Location

United States

Related Subject Headings

  • Receptors, Androgen
  • Racemases and Epimerases
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Phenotype
  • Oncology & Carcinogenesis
  • Neuroendocrine Tumors
  • Male
  • Ki-67 Antigen
  • Keratins