High-throughput acoustic separation of platelets from whole blood.
Publication
, Journal Article
Chen, Y; Wu, M; Ren, L; Liu, J; Whitley, PH; Wang, L; Huang, TJ
Published in: Lab on a chip
September 2016
Platelets contain growth factors which are important in biomedical and clinical applications. In this work, we present an acoustic separation device for high-throughput, non-invasive platelet isolation. In particular, we separated platelets from whole blood at a 10 mL min(-1) throughput, which is three orders of magnitude greater than that of existing acoustic-based platelet separation techniques. Without sample dilution, we observed more than 80% RBC/WBC removal and platelet recovery. High throughput, high separation efficiency, and biocompatibility make this device useful for many clinical applications.
Duke Scholars
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Published In
Lab on a chip
DOI
EISSN
1473-0189
ISSN
1473-0197
Publication Date
September 2016
Volume
16
Issue
18
Start / End Page
3466 / 3472
Related Subject Headings
- Humans
- Cell Separation
- Blood Platelets
- Analytical Chemistry
- Acoustics
- 40 Engineering
- 34 Chemical sciences
- 09 Engineering
- 03 Chemical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Chen, Y., Wu, M., Ren, L., Liu, J., Whitley, P. H., Wang, L., & Huang, T. J. (2016). High-throughput acoustic separation of platelets from whole blood. Lab on a Chip, 16(18), 3466–3472. https://doi.org/10.1039/c6lc00682e
Published In
Lab on a chip
DOI
EISSN
1473-0189
ISSN
1473-0197
Publication Date
September 2016
Volume
16
Issue
18
Start / End Page
3466 / 3472
Related Subject Headings
- Humans
- Cell Separation
- Blood Platelets
- Analytical Chemistry
- Acoustics
- 40 Engineering
- 34 Chemical sciences
- 09 Engineering
- 03 Chemical Sciences