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Role of C1q complement fixing antibody assay in therapeutic plasma exchange management of pediatric cardiac antibody mediated rejection.

Publication ,  Journal Article
Onwuemene, OA; Heath, DM; Hartman, C; Wong, ECC
Published in: J Clin Apher
August 2017

Pediatric cardiac transplant patients with antibody-mediated rejection (AMR) often undergo therapeutic plasma exchange (TPE) to remove pathologic donor specific antibodies (DSA). In cases where DSA persist, it is unclear how long TPE should be continued. We report a case of a 17-year-old cardiac transplant patient with AMR where use of a C1q complement fixing antibody assay helped guide TPE cessation. This report adds to the existing literature that highlights the potential clinical significance of C1q antibodies in AMR management.

Duke Scholars

Published In

J Clin Apher

DOI

EISSN

1098-1101

Publication Date

August 2017

Volume

32

Issue

4

Start / End Page

279 / 281

Location

United States

Related Subject Headings

  • Plasma Exchange
  • Male
  • Isoantibodies
  • Immunologic Tests
  • Humans
  • Heart Transplantation
  • Graft Rejection
  • Complement C1q
  • Cardiovascular System & Hematology
  • Adolescent
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Onwuemene, O. A., Heath, D. M., Hartman, C., & Wong, E. C. C. (2017). Role of C1q complement fixing antibody assay in therapeutic plasma exchange management of pediatric cardiac antibody mediated rejection. J Clin Apher, 32(4), 279–281. https://doi.org/10.1002/jca.21488
Onwuemene, Oluwatoyosi A., Deneen M. Heath, Carol Hartman, and Edward C. C. Wong. “Role of C1q complement fixing antibody assay in therapeutic plasma exchange management of pediatric cardiac antibody mediated rejection.J Clin Apher 32, no. 4 (August 2017): 279–81. https://doi.org/10.1002/jca.21488.
Onwuemene, Oluwatoyosi A., et al. “Role of C1q complement fixing antibody assay in therapeutic plasma exchange management of pediatric cardiac antibody mediated rejection.J Clin Apher, vol. 32, no. 4, Aug. 2017, pp. 279–81. Pubmed, doi:10.1002/jca.21488.
Journal cover image

Published In

J Clin Apher

DOI

EISSN

1098-1101

Publication Date

August 2017

Volume

32

Issue

4

Start / End Page

279 / 281

Location

United States

Related Subject Headings

  • Plasma Exchange
  • Male
  • Isoantibodies
  • Immunologic Tests
  • Humans
  • Heart Transplantation
  • Graft Rejection
  • Complement C1q
  • Cardiovascular System & Hematology
  • Adolescent