Localized force application reveals mechanically sensitive domains of Piezo1.
Publication
, Journal Article
Wu, J; Goyal, R; Grandl, J
Published in: Nat Commun
October 3, 2016
Piezos are mechanically activated ion channels that function as sensors of touch and pressure in various cell types. However, the precise mechanism and structures mediating mechanical activation and subsequent inactivation have not yet been identified. Here we use magnetic nanoparticles as localized transducers of mechanical force in combination with pressure-clamp electrophysiology to identify mechanically sensitive domains important for activation and inactivation.
Duke Scholars
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Published In
Nat Commun
DOI
EISSN
2041-1723
Publication Date
October 3, 2016
Volume
7
Start / End Page
12939
Location
England
Related Subject Headings
- Wolves
- Signal Transduction
- Rats
- Protein Domains
- Pressure
- Nanotechnology
- Nanoparticles
- Mice
- Mechanotransduction, Cellular
- Mechanical Phenomena
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NLM
Wu, J., Goyal, R., & Grandl, J. (2016). Localized force application reveals mechanically sensitive domains of Piezo1. Nat Commun, 7, 12939. https://doi.org/10.1038/ncomms12939
Wu, Jason, Raman Goyal, and Jörg Grandl. “Localized force application reveals mechanically sensitive domains of Piezo1.” Nat Commun 7 (October 3, 2016): 12939. https://doi.org/10.1038/ncomms12939.
Wu J, Goyal R, Grandl J. Localized force application reveals mechanically sensitive domains of Piezo1. Nat Commun. 2016 Oct 3;7:12939.
Wu, Jason, et al. “Localized force application reveals mechanically sensitive domains of Piezo1.” Nat Commun, vol. 7, Oct. 2016, p. 12939. Pubmed, doi:10.1038/ncomms12939.
Wu J, Goyal R, Grandl J. Localized force application reveals mechanically sensitive domains of Piezo1. Nat Commun. 2016 Oct 3;7:12939.
Published In
Nat Commun
DOI
EISSN
2041-1723
Publication Date
October 3, 2016
Volume
7
Start / End Page
12939
Location
England
Related Subject Headings
- Wolves
- Signal Transduction
- Rats
- Protein Domains
- Pressure
- Nanotechnology
- Nanoparticles
- Mice
- Mechanotransduction, Cellular
- Mechanical Phenomena