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Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV.

Publication ,  Journal Article
Matta, B; Lee, T-H; Patel, K
Published in: Curr HIV/AIDS Rep
October 2016

Patients with HIV have a proclivity to develop liver fibrosis, especially when associated with other conditions such as HCV, HBV, and NAFLD. Identifying HIV-infected patients with significant fibrosis or cirrhosis plays an important role in clinical and therapeutic decision-making. Liver biopsy is currently considered as the gold standard for fibrosis assessment but carries many shortcomings (cost, invasiveness, complications, false negative rate of 20 %). Multiple non-invasive methods of liver fibrosis assessment have been developed, but not all have been studied in HIV-infected individuals. Non-invasive liver fibrosis tools include both serologic-based testing scores (rely on direct and/or indirect markers) such as APRI, FIB4, FibroTest, FibroSpect II, HepaScore, or imaging-based methods such as vibration controlled liver elastography. There is validated data to support the use of non-invasive modalities of fibrosis assessment in HIV-HCV co-infected individuals for the exclusion of cirrhosis, but may be poorly reliable or not enough data exists for the assessment of other co-morbid disease processes.

Duke Scholars

Published In

Curr HIV/AIDS Rep

DOI

EISSN

1548-3576

Publication Date

October 2016

Volume

13

Issue

5

Start / End Page

279 / 288

Location

United States

Related Subject Headings

  • Virology
  • Liver Cirrhosis
  • Liver
  • Humans
  • Hepatitis C, Chronic
  • HIV Infections
  • Elasticity Imaging Techniques
  • Coinfection
  • Biopsy
  • Biomarkers
 

Citation

APA
Chicago
ICMJE
MLA
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Matta, B., Lee, T.-H., & Patel, K. (2016). Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Curr HIV/AIDS Rep, 13(5), 279–288. https://doi.org/10.1007/s11904-016-0329-5
Matta, Bassem, Tzu-Hao Lee, and Keyur Patel. “Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV.Curr HIV/AIDS Rep 13, no. 5 (October 2016): 279–88. https://doi.org/10.1007/s11904-016-0329-5.
Matta B, Lee T-H, Patel K. Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Curr HIV/AIDS Rep. 2016 Oct;13(5):279–88.
Matta, Bassem, et al. “Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV.Curr HIV/AIDS Rep, vol. 13, no. 5, Oct. 2016, pp. 279–88. Pubmed, doi:10.1007/s11904-016-0329-5.
Matta B, Lee T-H, Patel K. Use of Non-invasive Testing to Stage Liver Fibrosis in Patients with HIV. Curr HIV/AIDS Rep. 2016 Oct;13(5):279–288.
Journal cover image

Published In

Curr HIV/AIDS Rep

DOI

EISSN

1548-3576

Publication Date

October 2016

Volume

13

Issue

5

Start / End Page

279 / 288

Location

United States

Related Subject Headings

  • Virology
  • Liver Cirrhosis
  • Liver
  • Humans
  • Hepatitis C, Chronic
  • HIV Infections
  • Elasticity Imaging Techniques
  • Coinfection
  • Biopsy
  • Biomarkers