Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility.
Publication
, Journal Article
Everitt, JI; Goldsworthy, TL; Wolf, DC; Walker, CL
Published in: Toxicol Lett
December 1995
A class of genes, the so-called tumor suppressor genes or anti-oncogenes, was originally identified as being responsible for germ-line transmission of cancer susceptibility in humans. Tumor suppressor genes are recessive at the cellular level with respect to oncogenesis but often manifest as dominantly inherited familial cancer syndromes. This type of cancer syndrome arises in the Eker rat due to a genetic defect in the tuberous sclerosis 2 (Tsc2) gene. The Eker rat familial cancer syndrome serves as a unique animal model in which to study the molecular pathways of renal tubular epithelial carcinogenesis as well as a valuable tool for studies that examine how chemical carcinogens interact with cancer susceptibility genes.
Duke Scholars
Published In
Toxicol Lett
DOI
ISSN
0378-4274
Publication Date
December 1995
Volume
82-83
Start / End Page
621 / 625
Location
Netherlands
Related Subject Headings
- Tumor Suppressor Proteins
- Tuberous Sclerosis Complex 2 Protein
- Tuberous Sclerosis
- Toxicology
- Repressor Proteins
- Rats
- Kidney Neoplasms
- Genes, Tumor Suppressor
- Disease Models, Animal
- Carcinoma, Renal Cell
Citation
APA
Chicago
ICMJE
MLA
NLM
Everitt, J. I., Goldsworthy, T. L., Wolf, D. C., & Walker, C. L. (1995). Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility. Toxicol Lett, 82–83, 621–625. https://doi.org/10.1016/0378-4274(95)03506-0
Everitt, J. I., T. L. Goldsworthy, D. C. Wolf, and C. L. Walker. “Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility.” Toxicol Lett 82–83 (December 1995): 621–25. https://doi.org/10.1016/0378-4274(95)03506-0.
Everitt JI, Goldsworthy TL, Wolf DC, Walker CL. Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility. Toxicol Lett. 1995 Dec;82–83:621–5.
Everitt, J. I., et al. “Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility.” Toxicol Lett, vol. 82–83, Dec. 1995, pp. 621–25. Pubmed, doi:10.1016/0378-4274(95)03506-0.
Everitt JI, Goldsworthy TL, Wolf DC, Walker CL. Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility. Toxicol Lett. 1995 Dec;82–83:621–625.
Published In
Toxicol Lett
DOI
ISSN
0378-4274
Publication Date
December 1995
Volume
82-83
Start / End Page
621 / 625
Location
Netherlands
Related Subject Headings
- Tumor Suppressor Proteins
- Tuberous Sclerosis Complex 2 Protein
- Tuberous Sclerosis
- Toxicology
- Repressor Proteins
- Rats
- Kidney Neoplasms
- Genes, Tumor Suppressor
- Disease Models, Animal
- Carcinoma, Renal Cell