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Osteopontin expression in particle-induced lung disease.

Publication ,  Journal Article
Mangum, J; Bermudez, E; Sar, M; Everitt, J
Published in: Exp Lung Res
2004

Osteopontin (OPN) is a secreted cytokine with cell adhesive and chemoattractive functions whose expression is induced by a variety of environmental toxicants. It has been implicated in the pathogenesis of several pulmonary granulomatous and fibrotic conditions. For these reasons the authors investigated OPN expression in experimental particle-induced lung disease using a titanium dioxide exposure model in the rat. Under exposure conditions that resulted in fibroproliferative lung disease, rats had significant increases in total lung OPN mRNA expression and increased levels of OPN protein in bronchoalveolar lavage fluid (BALF) prior to the development of lesions. OPN immunoreactivity studies of lesion development provide evidence that this multifunctional cytokine may be important in the pathogenesis of particle-induced lung disease. Findings suggest that OPN may serve as an important biomarker for particle-induced lung disease.

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Published In

Exp Lung Res

DOI

ISSN

0190-2148

Publication Date

2004

Volume

30

Issue

7

Start / End Page

585 / 598

Location

England

Related Subject Headings

  • Titanium
  • Specific Pathogen-Free Organisms
  • Sialoglycoproteins
  • Respiratory System
  • Rats, Inbred F344
  • Rats
  • Pulmonary Fibrosis
  • Osteopontin
  • Lung
  • Immunohistochemistry
 

Citation

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Mangum, J., Bermudez, E., Sar, M., & Everitt, J. (2004). Osteopontin expression in particle-induced lung disease. Exp Lung Res, 30(7), 585–598. https://doi.org/10.1080/01902140490476346
Mangum, James, Edilberto Bermudez, Madhabananda Sar, and Jeffrey Everitt. “Osteopontin expression in particle-induced lung disease.Exp Lung Res 30, no. 7 (2004): 585–98. https://doi.org/10.1080/01902140490476346.
Mangum J, Bermudez E, Sar M, Everitt J. Osteopontin expression in particle-induced lung disease. Exp Lung Res. 2004;30(7):585–98.
Mangum, James, et al. “Osteopontin expression in particle-induced lung disease.Exp Lung Res, vol. 30, no. 7, 2004, pp. 585–98. Pubmed, doi:10.1080/01902140490476346.
Mangum J, Bermudez E, Sar M, Everitt J. Osteopontin expression in particle-induced lung disease. Exp Lung Res. 2004;30(7):585–598.
Journal cover image

Published In

Exp Lung Res

DOI

ISSN

0190-2148

Publication Date

2004

Volume

30

Issue

7

Start / End Page

585 / 598

Location

England

Related Subject Headings

  • Titanium
  • Specific Pathogen-Free Organisms
  • Sialoglycoproteins
  • Respiratory System
  • Rats, Inbred F344
  • Rats
  • Pulmonary Fibrosis
  • Osteopontin
  • Lung
  • Immunohistochemistry