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Mesotheliomas induced in rats by the fibrous mineral erionite are independent from p53 alterations.

Publication ,  Journal Article
Kleymenova, EV; Horesovsky, G; Pylev, LN; Everitt, J
Published in: Cancer Lett
December 1, 1999

The development of human malignant mesothelioma (MM) is strongly associated with occupational or environmental exposure to certain natural mineral fibers, although the genetic mechanisms underlying this malignancy remain unclear. Although the p53 gene is frequently mutated in various tumors, human asbestos-associated MMs appear to develop independently from p53 alterations. The high mesotheliomagenic potency of natural fibrous mineral erionite is well established in humans and rodents, but no data regarding genetic alterations in erionite-associated tumors are currently available. Previous speculations that the oncogenic mechanisms underlying asbestos and erionite carcinogenesis may differ led us to examine whether the p53 gene is targeted in erionite carcinogenesis. Fifteen erionite-induced rat MMs as well as six cell lines derived from asbestos-induced and spontaneous rat MM were analyzed for p53 mutations by direct DNA sequencing and immunohistochemical analysis. Both approaches did not reveal p53 alterations in rat MM samples used in the study indicating that, similar to asbestos carcinogenesis, erionite carcinogenesis does not target the p53 tumor suppressor gene.

Duke Scholars

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

December 1, 1999

Volume

147

Issue

1-2

Start / End Page

55 / 61

Location

Ireland

Related Subject Headings

  • Zeolites
  • Tumor Suppressor Protein p53
  • Tumor Cells, Cultured
  • Sequence Analysis, DNA
  • Reverse Transcriptase Polymerase Chain Reaction
  • Rats, Wistar
  • Rats
  • RNA
  • Peritoneal Neoplasms
  • Oncology & Carcinogenesis
 

Citation

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MLA
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Kleymenova, E. V., Horesovsky, G., Pylev, L. N., & Everitt, J. (1999). Mesotheliomas induced in rats by the fibrous mineral erionite are independent from p53 alterations. Cancer Lett, 147(1–2), 55–61. https://doi.org/10.1016/s0304-3835(99)00275-x
Kleymenova, E. V., G. Horesovsky, L. N. Pylev, and J. Everitt. “Mesotheliomas induced in rats by the fibrous mineral erionite are independent from p53 alterations.Cancer Lett 147, no. 1–2 (December 1, 1999): 55–61. https://doi.org/10.1016/s0304-3835(99)00275-x.
Kleymenova EV, Horesovsky G, Pylev LN, Everitt J. Mesotheliomas induced in rats by the fibrous mineral erionite are independent from p53 alterations. Cancer Lett. 1999 Dec 1;147(1–2):55–61.
Kleymenova, E. V., et al. “Mesotheliomas induced in rats by the fibrous mineral erionite are independent from p53 alterations.Cancer Lett, vol. 147, no. 1–2, Dec. 1999, pp. 55–61. Pubmed, doi:10.1016/s0304-3835(99)00275-x.
Kleymenova EV, Horesovsky G, Pylev LN, Everitt J. Mesotheliomas induced in rats by the fibrous mineral erionite are independent from p53 alterations. Cancer Lett. 1999 Dec 1;147(1–2):55–61.
Journal cover image

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

December 1, 1999

Volume

147

Issue

1-2

Start / End Page

55 / 61

Location

Ireland

Related Subject Headings

  • Zeolites
  • Tumor Suppressor Protein p53
  • Tumor Cells, Cultured
  • Sequence Analysis, DNA
  • Reverse Transcriptase Polymerase Chain Reaction
  • Rats, Wistar
  • Rats
  • RNA
  • Peritoneal Neoplasms
  • Oncology & Carcinogenesis