Skip to main content

Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis.

Publication ,  Journal Article
Kirby, PJ; Shines, CJ; Taylor, GJ; Bousquet, RW; Price, HC; Everitt, JI; Morgan, DL
Published in: Exp Lung Res
December 2009

The mechanism(s) by which chronic inhalation of indium phosphide (InP) particles causes pleural fibrosis is not known. Few studies of InP pleural toxicity have been conducted because of the challenges in conducting particulate inhalation exposures, and because the pleural lesions developed slowly over the 2-year inhalation study. The authors investigated whether InP (1 mg/kg) administered by a single oropharyngeal aspiration would cause pleural fibrosis in male B6C3F1 mice. By 28 days after treatment, protein and lactate dehydrogenase (LDH) were significantly increased in bronchoalveolar lavage fluid (BALF), but were unchanged in pleural lavage fluid (PLF). A pronounced pleural effusion characterized by significant increases in cytokines and a 3.7-fold increase in cell number was detected 28 days after InP treatment. Aspiration of soluble InCl(3) caused a similar delayed pleural effusion; however, other soluble metals, insoluble particles, and fibers did not. The effusion caused by InP was accompanied by areas of pleural thickening and inflammation at day 28, and by pleural fibrosis at day 98. Aspiration of InP produced pleural fibrosis that was histologically similar to lesions caused by chronic inhalation exposure, and in a shorter time period. This oropharyngeal aspiration model was used to provide an initial characterization of the progression of pleural lesions caused by InP.

Duke Scholars

Published In

Exp Lung Res

DOI

EISSN

1521-0499

Publication Date

December 2009

Volume

35

Issue

10

Start / End Page

858 / 882

Location

England

Related Subject Headings

  • Time Factors
  • Respiratory System
  • Pleurisy
  • Pleural Effusion
  • Pleura
  • Phosphines
  • Particulate Matter
  • Mice
  • Male
  • L-Lactate Dehydrogenase
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kirby, P. J., Shines, C. J., Taylor, G. J., Bousquet, R. W., Price, H. C., Everitt, J. I., & Morgan, D. L. (2009). Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis. Exp Lung Res, 35(10), 858–882. https://doi.org/10.3109/01902140902980961
Kirby, Patrick J., Cassandra J. Shines, Genie J. Taylor, Ronald W. Bousquet, Herman C. Price, Jeffrey I. Everitt, and Daniel L. Morgan. “Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis.Exp Lung Res 35, no. 10 (December 2009): 858–82. https://doi.org/10.3109/01902140902980961.
Kirby PJ, Shines CJ, Taylor GJ, Bousquet RW, Price HC, Everitt JI, et al. Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis. Exp Lung Res. 2009 Dec;35(10):858–82.
Kirby, Patrick J., et al. “Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis.Exp Lung Res, vol. 35, no. 10, Dec. 2009, pp. 858–82. Pubmed, doi:10.3109/01902140902980961.
Kirby PJ, Shines CJ, Taylor GJ, Bousquet RW, Price HC, Everitt JI, Morgan DL. Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis. Exp Lung Res. 2009 Dec;35(10):858–882.

Published In

Exp Lung Res

DOI

EISSN

1521-0499

Publication Date

December 2009

Volume

35

Issue

10

Start / End Page

858 / 882

Location

England

Related Subject Headings

  • Time Factors
  • Respiratory System
  • Pleurisy
  • Pleural Effusion
  • Pleura
  • Phosphines
  • Particulate Matter
  • Mice
  • Male
  • L-Lactate Dehydrogenase