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Isolation of Enterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production.

Publication ,  Journal Article
Mellencamp, MA; Roccaforte, JS; Preheim, LC; Sanders, CC; Anene, CA; Bittner, MJ
Published in: Eur J Clin Microbiol Infect Dis
November 1990

This report describes a patient with nosocomial meningitis from whom four distinct isolates of Enterobacter aerogenes were recovered over a complicated course of chemotherapy. The initial isolate was susceptible to expanded spectrum beta-lactams despite constitutive production of high levels of beta-lactamase. Resistant isolates recovered during antibiotic therapy had lost a 42,000 outer membrane protein. These data suggest that b-lactam susceptibility in the original isolate was due to "hyperpermeability" mediated by the 42,000 Dalton protein.

Duke Scholars

Published In

Eur J Clin Microbiol Infect Dis

DOI

ISSN

0934-9723

Publication Date

November 1990

Volume

9

Issue

11

Start / End Page

827 / 830

Location

Germany

Related Subject Headings

  • beta-Lactams
  • beta-Lactamases
  • Middle Aged
  • Microbiology
  • Meningitis
  • Male
  • Humans
  • Enterobacteriaceae Infections
  • Enterobacter
  • Drug Resistance, Microbial
 

Citation

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ICMJE
MLA
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Mellencamp, M. A., Roccaforte, J. S., Preheim, L. C., Sanders, C. C., Anene, C. A., & Bittner, M. J. (1990). Isolation of Enterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production. Eur J Clin Microbiol Infect Dis, 9(11), 827–830. https://doi.org/10.1007/BF01967384
Mellencamp, M. A., J. S. Roccaforte, L. C. Preheim, C. C. Sanders, C. A. Anene, and M. J. Bittner. “Isolation of Enterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production.Eur J Clin Microbiol Infect Dis 9, no. 11 (November 1990): 827–30. https://doi.org/10.1007/BF01967384.
Mellencamp MA, Roccaforte JS, Preheim LC, Sanders CC, Anene CA, Bittner MJ. Isolation of Enterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production. Eur J Clin Microbiol Infect Dis. 1990 Nov;9(11):827–30.
Mellencamp, M. A., et al. “Isolation of Enterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production.Eur J Clin Microbiol Infect Dis, vol. 9, no. 11, Nov. 1990, pp. 827–30. Pubmed, doi:10.1007/BF01967384.
Mellencamp MA, Roccaforte JS, Preheim LC, Sanders CC, Anene CA, Bittner MJ. Isolation of Enterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production. Eur J Clin Microbiol Infect Dis. 1990 Nov;9(11):827–830.
Journal cover image

Published In

Eur J Clin Microbiol Infect Dis

DOI

ISSN

0934-9723

Publication Date

November 1990

Volume

9

Issue

11

Start / End Page

827 / 830

Location

Germany

Related Subject Headings

  • beta-Lactams
  • beta-Lactamases
  • Middle Aged
  • Microbiology
  • Meningitis
  • Male
  • Humans
  • Enterobacteriaceae Infections
  • Enterobacter
  • Drug Resistance, Microbial