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Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee.

Publication ,  Journal Article
Ittmann, M; Huang, J; Radaelli, E; Martin, P; Signoretti, S; Sullivan, R; Simons, BW; Ward, JM; Robinson, BD; Chu, GC; Loda, M; Thomas, G ...
Published in: Cancer Res
May 1, 2013

Animal models, particularly mouse models, play a central role in the study of the etiology, prevention, and treatment of human prostate cancer. While tissue culture models are extremely useful in understanding the biology of prostate cancer, they cannot recapitulate the complex cellular interactions within the tumor microenvironment that play a key role in cancer initiation and progression. The National Cancer Institute (NCI) Mouse Models of Human Cancers Consortium convened a group of human and veterinary pathologists to review the current animal models of prostate cancer and make recommendations about the pathologic analysis of these models. More than 40 different models with 439 samples were reviewed, including genetically engineered mouse models, xenograft, rat, and canine models. Numerous relevant models have been developed over the past 15 years, and each approach has strengths and weaknesses. Analysis of multiple genetically engineered models has shown that reactive stroma formation is present in all the models developing invasive carcinomas. In addition, numerous models with multiple genetic alterations display aggressive phenotypes characterized by sarcomatoid carcinomas and metastases, which is presumably a histologic manifestation of epithelial-mesenchymal transition. The significant progress in development of improved models of prostate cancer has already accelerated our understanding of the complex biology of prostate cancer and promises to enhance development of new approaches to prevention, detection, and treatment of this common malignancy.

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Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

May 1, 2013

Volume

73

Issue

9

Start / End Page

2718 / 2736

Location

United States

Related Subject Headings

  • Societies, Medical
  • Rats
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Oncogenes
  • New York
  • Neoplasm Transplantation
  • Neoplasm Metastasis
  • Mice
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Ittmann, M., Huang, J., Radaelli, E., Martin, P., Signoretti, S., Sullivan, R., … Cardiff, R. D. (2013). Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee. Cancer Res, 73(9), 2718–2736. https://doi.org/10.1158/0008-5472.CAN-12-4213
Ittmann, Michael, Jiaoti Huang, Enrico Radaelli, Philip Martin, Sabina Signoretti, Ruth Sullivan, Brian W. Simons, et al. “Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee.Cancer Res 73, no. 9 (May 1, 2013): 2718–36. https://doi.org/10.1158/0008-5472.CAN-12-4213.
Ittmann M, Huang J, Radaelli E, Martin P, Signoretti S, Sullivan R, et al. Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee. Cancer Res. 2013 May 1;73(9):2718–36.
Ittmann, Michael, et al. “Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee.Cancer Res, vol. 73, no. 9, May 2013, pp. 2718–36. Pubmed, doi:10.1158/0008-5472.CAN-12-4213.
Ittmann M, Huang J, Radaelli E, Martin P, Signoretti S, Sullivan R, Simons BW, Ward JM, Robinson BD, Chu GC, Loda M, Thomas G, Borowsky A, Cardiff RD. Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee. Cancer Res. 2013 May 1;73(9):2718–2736.

Published In

Cancer Res

DOI

EISSN

1538-7445

Publication Date

May 1, 2013

Volume

73

Issue

9

Start / End Page

2718 / 2736

Location

United States

Related Subject Headings

  • Societies, Medical
  • Rats
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Oncogenes
  • New York
  • Neoplasm Transplantation
  • Neoplasm Metastasis
  • Mice
  • Male