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Association of Dry Eye Tests With Extraocular Signs Among 3514 Participants in the Sjögren's Syndrome International Registry.

Publication ,  Journal Article
Bunya, VY; Bhosai, SJ; Heidenreich, AM; Kitagawa, K; Larkin, GB; Lietman, TM; Gaynor, BD; Akpek, EK; Massaro-Giordano, M; Srinivasan, M ...
Published in: American journal of ophthalmology
December 2016

To identify a screening strategy for dry eye patients with a high likelihood of having Sjogren syndrome (SS) through the evaluation of the association of ocular surface tests with the extraocular signs used for the diagnosis of SS.Multicenter cross-sectional study.The Sjogren's International Clinical Collaborative Alliance (SICCA) registry enrolled 3514 participants with SS or possible SS from 9 international academic sites. Ocular surface evaluation included Schirmer I testing, tear breakup time (TBUT), and staining of the cornea (0-6 points) and conjunctiva (0-6 points). Multivariate logistic regression analysis was performed to identify predictive factors for (1) histopathologic changes on labial salivary gland (LSG) biopsies (positive = focus score of ≥1 focus/4 mm2) and (2) positive anti-SSA/B serology.The adjusted odds of having a positive LSG biopsy were significantly higher among those with an abnormal Schirmer I test (adjusted OR = 1.26, 95% CI 1.05-1.51, P = .014) and positive conjunctival staining (for each additional unit of staining 1.46; 95% CI 1.39-1.53, P < .001) or corneal staining (for each additional unit of staining 1.14; 95% CI 1.08-1.21, P < .001). The odds of having a positive serology were significantly higher among those with an abnormal Schirmer I test (adjusted OR = 1.3; 95% CI 1.09-1.54, P = .004) and conjunctival staining (adjusted OR = 1.51; 95% CI 1.43-1.58, P < .001).In addition to corneal staining, which was associated with a higher likelihood of having a positive LSG biopsy, conjunctival staining and abnormal Schirmer I testing are of critical importance to include when screening dry eye patients for possible SS, as they were associated with a higher likelihood of having a positive LSG biopsy and serology.

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Published In

American journal of ophthalmology

DOI

EISSN

1879-1891

ISSN

0002-9394

Publication Date

December 2016

Volume

172

Start / End Page

87 / 93

Related Subject Headings

  • Young Adult
  • Tears
  • Sjogren's Syndrome
  • Severity of Illness Index
  • Registries
  • Ophthalmology & Optometry
  • Male
  • Incidence
  • Humans
  • Global Health
 

Citation

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ICMJE
MLA
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Bunya, V. Y., Bhosai, S. J., Heidenreich, A. M., Kitagawa, K., Larkin, G. B., Lietman, T. M., … Sjögren’s International Collaborative Clinical Alliance (SICCA) Study Group, . (2016). Association of Dry Eye Tests With Extraocular Signs Among 3514 Participants in the Sjögren's Syndrome International Registry. American Journal of Ophthalmology, 172, 87–93. https://doi.org/10.1016/j.ajo.2016.09.013
Bunya, Vatinee Y., Satasuk Joy Bhosai, Ana Maria Heidenreich, Kazuko Kitagawa, Genevieve B. Larkin, Thomas M. Lietman, Bruce D. Gaynor, et al. “Association of Dry Eye Tests With Extraocular Signs Among 3514 Participants in the Sjögren's Syndrome International Registry.American Journal of Ophthalmology 172 (December 2016): 87–93. https://doi.org/10.1016/j.ajo.2016.09.013.
Bunya VY, Bhosai SJ, Heidenreich AM, Kitagawa K, Larkin GB, Lietman TM, et al. Association of Dry Eye Tests With Extraocular Signs Among 3514 Participants in the Sjögren's Syndrome International Registry. American journal of ophthalmology. 2016 Dec;172:87–93.
Bunya, Vatinee Y., et al. “Association of Dry Eye Tests With Extraocular Signs Among 3514 Participants in the Sjögren's Syndrome International Registry.American Journal of Ophthalmology, vol. 172, Dec. 2016, pp. 87–93. Epmc, doi:10.1016/j.ajo.2016.09.013.
Bunya VY, Bhosai SJ, Heidenreich AM, Kitagawa K, Larkin GB, Lietman TM, Gaynor BD, Akpek EK, Massaro-Giordano M, Srinivasan M, Porco TC, Whitcher JP, Shiboski SC, Criswell LA, Shiboski CH, Sjögren’s International Collaborative Clinical Alliance (SICCA) Study Group. Association of Dry Eye Tests With Extraocular Signs Among 3514 Participants in the Sjögren's Syndrome International Registry. American journal of ophthalmology. 2016 Dec;172:87–93.
Journal cover image

Published In

American journal of ophthalmology

DOI

EISSN

1879-1891

ISSN

0002-9394

Publication Date

December 2016

Volume

172

Start / End Page

87 / 93

Related Subject Headings

  • Young Adult
  • Tears
  • Sjogren's Syndrome
  • Severity of Illness Index
  • Registries
  • Ophthalmology & Optometry
  • Male
  • Incidence
  • Humans
  • Global Health