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Metabolic interactions with cancer epigenetics.

Publication ,  Journal Article
Gao, X; Reid, MA; Kong, M; Locasale, JW
Published in: Molecular aspects of medicine
April 2017

Cancer cells have epigenetic alterations that are known to drive cancer progression. The reversibility of the epigenetic posttranslational modifications on chromatin and DNA renders targeting these modifications an attractive means for cancer therapy. Cellular epigenetic status interacts with cell metabolism, and we are now beginning to understand the nature of how this interaction occurs and the biological contexts that mediate its function. Given the tremendous interest in understanding and targeting metabolic reprogramming in cancer, this nexus also provides opportunities for exploring the liabilities of cancers. This review summarizes recent developments in our understanding of the interaction of cancer metabolism and epigenetics.

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Published In

Molecular aspects of medicine

DOI

EISSN

1872-9452

ISSN

0098-2997

Publication Date

April 2017

Volume

54

Start / End Page

50 / 57

Related Subject Headings

  • Neoplasms
  • Models, Biological
  • Metabolome
  • Humans
  • Histones
  • Epigenesis, Genetic
  • DNA Methylation
  • Biochemistry & Molecular Biology
  • Animals
  • 32 Biomedical and clinical sciences
 

Citation

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Gao, X., Reid, M. A., Kong, M., & Locasale, J. W. (2017). Metabolic interactions with cancer epigenetics. Molecular Aspects of Medicine, 54, 50–57. https://doi.org/10.1016/j.mam.2016.09.001
Gao, Xia, Michael A. Reid, Mei Kong, and Jason W. Locasale. “Metabolic interactions with cancer epigenetics.Molecular Aspects of Medicine 54 (April 2017): 50–57. https://doi.org/10.1016/j.mam.2016.09.001.
Gao X, Reid MA, Kong M, Locasale JW. Metabolic interactions with cancer epigenetics. Molecular aspects of medicine. 2017 Apr;54:50–7.
Gao, Xia, et al. “Metabolic interactions with cancer epigenetics.Molecular Aspects of Medicine, vol. 54, Apr. 2017, pp. 50–57. Epmc, doi:10.1016/j.mam.2016.09.001.
Gao X, Reid MA, Kong M, Locasale JW. Metabolic interactions with cancer epigenetics. Molecular aspects of medicine. 2017 Apr;54:50–57.
Journal cover image

Published In

Molecular aspects of medicine

DOI

EISSN

1872-9452

ISSN

0098-2997

Publication Date

April 2017

Volume

54

Start / End Page

50 / 57

Related Subject Headings

  • Neoplasms
  • Models, Biological
  • Metabolome
  • Humans
  • Histones
  • Epigenesis, Genetic
  • DNA Methylation
  • Biochemistry & Molecular Biology
  • Animals
  • 32 Biomedical and clinical sciences