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Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI).

Publication ,  Journal Article
Peterson, CT; Lucas, J; John-Williams, LS; Thompson, JW; Moseley, MA; Patel, S; Peterson, SN; Porter, V; Schadt, EE; Mills, PJ; Tanzi, RE ...
Published in: Sci Rep
September 9, 2016

The effects of integrative medicine practices such as meditation and Ayurveda on human physiology are not fully understood. The aim of this study was to identify altered metabolomic profiles following an Ayurveda-based intervention. In the experimental group, 65 healthy male and female subjects participated in a 6-day Panchakarma-based Ayurvedic intervention which included herbs, vegetarian diet, meditation, yoga, and massage. A set of 12 plasma phosphatidylcholines decreased (adjusted p < 0.01) post-intervention in the experimental (n = 65) compared to control group (n = 54) after Bonferroni correction for multiple testing; within these compounds, the phosphatidylcholine with the greatest decrease in abundance was PC ae C36:4 (delta = -0.34). Application of a 10% FDR revealed an additional 57 metabolites that were differentially abundant between groups. Pathway analysis suggests that the intervention results in changes in metabolites across many pathways such as phospholipid biosynthesis, choline metabolism, and lipoprotein metabolism. The observed plasma metabolomic alterations may reflect a Panchakarma-induced modulation of metabotypes. Panchakarma promoted statistically significant changes in plasma levels of phosphatidylcholines, sphingomyelins and others in just 6 days. Forthcoming studies that integrate metabolomics with genomic, microbiome and physiological parameters may facilitate a broader systems-level understanding and mechanistic insights into these integrative practices that are employed to promote health and well-being.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

September 9, 2016

Volume

6

Start / End Page

32609

Location

England

Related Subject Headings

  • Yoga
  • Sphingomyelins
  • Plants, Medicinal
  • Phosphatidylcholines
  • Metabolomics
  • Meditation
  • Medicine, Ayurvedic
  • Massage
  • Male
  • Lipoproteins
 

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Peterson, C. T., Lucas, J., John-Williams, L. S., Thompson, J. W., Moseley, M. A., Patel, S., … Chopra, D. (2016). Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI). Sci Rep, 6, 32609. https://doi.org/10.1038/srep32609
Peterson, Christine Tara, Joseph Lucas, Lisa St John-Williams, J Will Thompson, M Arthur Moseley, Sheila Patel, Scott N. Peterson, et al. “Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI).Sci Rep 6 (September 9, 2016): 32609. https://doi.org/10.1038/srep32609.
Peterson CT, Lucas J, John-Williams LS, Thompson JW, Moseley MA, Patel S, Peterson SN, Porter V, Schadt EE, Mills PJ, Tanzi RE, Doraiswamy PM, Chopra D. Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI). Sci Rep. 2016 Sep 9;6:32609.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

September 9, 2016

Volume

6

Start / End Page

32609

Location

England

Related Subject Headings

  • Yoga
  • Sphingomyelins
  • Plants, Medicinal
  • Phosphatidylcholines
  • Metabolomics
  • Meditation
  • Medicine, Ayurvedic
  • Massage
  • Male
  • Lipoproteins