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Risk factors associated with plasma omega-3 fatty acid levels in patients with suspected coronary artery disease.

Publication ,  Journal Article
Chaudhary, R; Saadin, K; Bliden, KP; Harris, WS; Dinh, B; Sharma, T; Tantry, US; Gurbel, PA
Published in: Prostaglandins Leukot Essent Fatty Acids
October 2016

INTRODUCTION: We sought to determine the associations between plasma eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels and various cardiovascular risk factors and with the use of fish oil supplements (FOS). PATIENTS AND METHODS: Patients with suspected coronary artery disease (CAD) undergoing cardiac catheterization (n=433) were studied. Serum fatty acid (FA) composition, the concentrations of lipids and biomarkers of oxidative stress, and dietary/lifestyle factors were measured. RESULTS: FOS use was associated with a higher plasma EPA+DHA levels (3.7±1.5 vs. 2.6±1.1%, p<0.0001). However, there was no relationship between FOS dose (mg/day) and EPA+DHA levels in 76 patients reporting FOS use (r=-0.21, p=0.07). Lower levels were inversely associated with risk factor profiles including lower ApoB100/ApoA1 ratios (p<0.001). DISCUSSION AND CONCLUSIONS: Higher EPA+DHA levels characterized patients with lower CAD risk. The lack of relations between FOS dose and plasma EPA+DHA levels likely reflects uncaptured variability in EPA+DHA content of supplements.

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Published In

Prostaglandins Leukot Essent Fatty Acids

DOI

EISSN

1532-2823

Publication Date

October 2016

Volume

113

Start / End Page

40 / 45

Location

Scotland

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Nutrition & Dietetics
  • Middle Aged
  • Male
  • Life Style
  • Humans
  • Fish Oils
  • Female
  • Eicosapentaenoic Acid
 

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Chaudhary, R., Saadin, K., Bliden, K. P., Harris, W. S., Dinh, B., Sharma, T., … Gurbel, P. A. (2016). Risk factors associated with plasma omega-3 fatty acid levels in patients with suspected coronary artery disease. Prostaglandins Leukot Essent Fatty Acids, 113, 40–45. https://doi.org/10.1016/j.plefa.2016.08.009
Chaudhary, Rahul, Katayoon Saadin, Kevin P. Bliden, William S. Harris, Bao Dinh, Tushar Sharma, Udaya S. Tantry, and Paul A. Gurbel. “Risk factors associated with plasma omega-3 fatty acid levels in patients with suspected coronary artery disease.Prostaglandins Leukot Essent Fatty Acids 113 (October 2016): 40–45. https://doi.org/10.1016/j.plefa.2016.08.009.
Chaudhary R, Saadin K, Bliden KP, Harris WS, Dinh B, Sharma T, et al. Risk factors associated with plasma omega-3 fatty acid levels in patients with suspected coronary artery disease. Prostaglandins Leukot Essent Fatty Acids. 2016 Oct;113:40–5.
Chaudhary, Rahul, et al. “Risk factors associated with plasma omega-3 fatty acid levels in patients with suspected coronary artery disease.Prostaglandins Leukot Essent Fatty Acids, vol. 113, Oct. 2016, pp. 40–45. Pubmed, doi:10.1016/j.plefa.2016.08.009.
Chaudhary R, Saadin K, Bliden KP, Harris WS, Dinh B, Sharma T, Tantry US, Gurbel PA. Risk factors associated with plasma omega-3 fatty acid levels in patients with suspected coronary artery disease. Prostaglandins Leukot Essent Fatty Acids. 2016 Oct;113:40–45.
Journal cover image

Published In

Prostaglandins Leukot Essent Fatty Acids

DOI

EISSN

1532-2823

Publication Date

October 2016

Volume

113

Start / End Page

40 / 45

Location

Scotland

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Nutrition & Dietetics
  • Middle Aged
  • Male
  • Life Style
  • Humans
  • Fish Oils
  • Female
  • Eicosapentaenoic Acid