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Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses.

Publication ,  Journal Article
Yang, J; Lin, X; Pan, Y; Wang, J; Chen, P; Huang, H; Xue, H-H; Gao, J; Zhong, X-P
Published in: Elife
September 30, 2016

T follicular helper (Tfh) cells play critical roles for germinal center responses and effective humoral immunity. We report here that mTOR in CD4 T cells is essential for Tfh differentiation. In Mtorf/f-Cd4Cre mice, both constitutive and inducible Tfh differentiation is severely impaired, leading to defective germinal center B cell formation and antibody production. Moreover, both mTORC1 and mTORC2 contribute to Tfh and GC B cell development but may do so via distinct mechanisms. mTORC1 mainly promotes CD4 T cell proliferation to reach the cell divisions necessary for Tfh differentiation, while Rictor/mTORC2 regulates Tfh differentiation by promoting Akt activation and TCF1 expression without grossly influencing T cell proliferation. Together, our results reveal crucial but distinct roles for mTORC1 and mTORC2 in CD4 T cells during Tfh differentiation and germinal center responses.

Duke Scholars

Published In

Elife

DOI

EISSN

2050-084X

Publication Date

September 30, 2016

Volume

5

Location

England

Related Subject Headings

  • T-Lymphocytes, Helper-Inducer
  • Mice
  • Mechanistic Target of Rapamycin Complex 2
  • Mechanistic Target of Rapamycin Complex 1
  • Germinal Center
  • Cell Differentiation
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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Yang, J., Lin, X., Pan, Y., Wang, J., Chen, P., Huang, H., … Zhong, X.-P. (2016). Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses. Elife, 5. https://doi.org/10.7554/eLife.17936
Yang, Jialong, Xingguang Lin, Yun Pan, Jinli Wang, Pengcheng Chen, Hongxiang Huang, Hai-Hui Xue, Jimin Gao, and Xiao-Ping Zhong. “Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses.Elife 5 (September 30, 2016). https://doi.org/10.7554/eLife.17936.
Yang J, Lin X, Pan Y, Wang J, Chen P, Huang H, et al. Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses. Elife. 2016 Sep 30;5.
Yang, Jialong, et al. “Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses.Elife, vol. 5, Sept. 2016. Pubmed, doi:10.7554/eLife.17936.
Yang J, Lin X, Pan Y, Wang J, Chen P, Huang H, Xue H-H, Gao J, Zhong X-P. Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses. Elife. 2016 Sep 30;5.

Published In

Elife

DOI

EISSN

2050-084X

Publication Date

September 30, 2016

Volume

5

Location

England

Related Subject Headings

  • T-Lymphocytes, Helper-Inducer
  • Mice
  • Mechanistic Target of Rapamycin Complex 2
  • Mechanistic Target of Rapamycin Complex 1
  • Germinal Center
  • Cell Differentiation
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences