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No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis.

Publication ,  Journal Article
Loley, C; Alver, M; Assimes, TL; Bjonnes, A; Goel, A; Gustafsson, S; Hernesniemi, J; Hopewell, JC; Kanoni, S; Kleber, ME; Lau, KW; Lu, Y ...
Published in: Sci Rep
October 12, 2016

In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have only one. Also, one of the female X chromosomes may be inactivated. Therefore, special test statistics and quality control procedures are required. Thus, little is known about the role of X-chromosomal variants in CAD. To fill this gap, we conducted a comprehensive X-chromosome-wide meta-analysis including more than 43,000 CAD cases and 58,000 controls from 35 international study cohorts. For quality control, sex-specific filters were used to adequately take the special structure of X-chromosomal data into account. For single study analyses, several logistic regression models were calculated allowing for inactivation of one female X-chromosome, adjusting for sex and investigating interactions between sex and genetic variants. Then, meta-analyses including all 35 studies were conducted using random effects models. None of the investigated models revealed genome-wide significant associations for any variant. Although we analyzed the largest-to-date sample, currently available methods were not able to detect any associations of X-chromosomal variants with CAD.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

October 12, 2016

Volume

6

Start / End Page

35278

Location

England

Related Subject Headings

  • Male
  • Internationality
  • Humans
  • Female
  • Coronary Artery Disease
  • Cohort Studies
  • Chromosomes, Human, X
 

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Loley, C., Alver, M., Assimes, T. L., Bjonnes, A., Goel, A., Gustafsson, S., … König, I. R. (2016). No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis. Sci Rep, 6, 35278. https://doi.org/10.1038/srep35278
Loley, Christina, Maris Alver, Themistocles L. Assimes, Andrew Bjonnes, Anuj Goel, Stefan Gustafsson, Jussi Hernesniemi, et al. “No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis.Sci Rep 6 (October 12, 2016): 35278. https://doi.org/10.1038/srep35278.
Loley C, Alver M, Assimes TL, Bjonnes A, Goel A, Gustafsson S, et al. No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis. Sci Rep. 2016 Oct 12;6:35278.
Loley, Christina, et al. “No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis.Sci Rep, vol. 6, Oct. 2016, p. 35278. Pubmed, doi:10.1038/srep35278.
Loley C, Alver M, Assimes TL, Bjonnes A, Goel A, Gustafsson S, Hernesniemi J, Hopewell JC, Kanoni S, Kleber ME, Lau KW, Lu Y, Lyytikäinen L-P, Nelson CP, Nikpay M, Qu L, Salfati E, Scholz M, Tukiainen T, Willenborg C, Won H-H, Zeng L, Zhang W, Anand SS, Beutner F, Bottinger EP, Clarke R, Dedoussis G, Do R, Esko T, Eskola M, Farrall M, Gauguier D, Giedraitis V, Granger CB, Hall AS, Hamsten A, Hazen SL, Huang J, Kähönen M, Kyriakou T, Laaksonen R, Lind L, Lindgren C, Magnusson PKE, Marouli E, Mihailov E, Morris AP, Nikus K, Pedersen N, Rallidis L, Salomaa V, Shah SH, Stewart AFR, Thompson JR, Zalloua PA, Chambers JC, Collins R, Ingelsson E, Iribarren C, Karhunen PJ, Kooner JS, Lehtimäki T, Loos RJF, März W, McPherson R, Metspalu A, Reilly MP, Ripatti S, Sanghera DK, Thiery J, Watkins H, Deloukas P, Kathiresan S, Samani NJ, Schunkert H, Erdmann J, König IR. No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis. Sci Rep. 2016 Oct 12;6:35278.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

October 12, 2016

Volume

6

Start / End Page

35278

Location

England

Related Subject Headings

  • Male
  • Internationality
  • Humans
  • Female
  • Coronary Artery Disease
  • Cohort Studies
  • Chromosomes, Human, X