Skip to main content
Journal cover image

Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis.

Publication ,  Journal Article
Davidson, M; Min, Y-I; Holbrook, JT; Van Natta, M; Quinn, TC; Murphy, RL; Welch, W; Jabs, DA; Meinert, CL ...
Published in: J Infect Dis
October 1, 2002

Filgrastim, or granulocyte colony-stimulating factor, reverses neutropenia associated with human immunodeficiency virus type 1 (HIV-1) and cytomegalovirus (CMV) infections. During a trial of anti-CMV retinitis therapies coadministered with antiretroviral therapy, 2-4 plasma specimens of HIV-1 RNA were collected from 36 HIV-1-infected patients receiving filgrastim to prevent neutropenia and from 36 patients not receiving filgrastim. For both groups, the crude mean and mean rate of change of HIV-1 log(10) RNA levels were similar. Adjustment for covariates (CD4(+) T cell lymphocytes, virus load at enrollment, level of neutropenia and antiretroviral therapy [mainly non-highly active antiretroviral therapy], and anti-CMV therapy during follow-up) resulted in a mean log(10) HIV-1 RNA level for individuals receiving filgrastim versus those not receiving the drug of 5.11 versus 4.87 (P=.12) and respective log mean rates of change per month of -0.08 versus -0.21 (P=.08). This latter difference has borderline statistical significance, which suggests that filgrastim may reduce the decline of HIV-1 RNA loads.

Duke Scholars

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

October 1, 2002

Volume

186

Issue

7

Start / End Page

1013 / 1018

Location

United States

Related Subject Headings

  • Viral Load
  • Treatment Outcome
  • Recombinant Proteins
  • RNA, Viral
  • Neutropenia
  • Microbiology
  • Male
  • Humans
  • HIV-1
  • Granulocyte Colony-Stimulating Factor
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Davidson, M., Min, Y.-I., Holbrook, J. T., Van Natta, M., Quinn, T. C., Murphy, R. L., … Studies of Ocular Complications of AIDS Research Group, . (2002). Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis. J Infect Dis, 186(7), 1013–1018. https://doi.org/10.1086/342956
Davidson, Michael, Yuan-I Min, Janet T. Holbrook, Mark Van Natta, Thomas C. Quinn, Robert L. Murphy, William Welch, Douglas A. Jabs, Curtis L. Meinert, and Curtis L. Studies of Ocular Complications of AIDS Research Group. “Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis.J Infect Dis 186, no. 7 (October 1, 2002): 1013–18. https://doi.org/10.1086/342956.
Davidson M, Min Y-I, Holbrook JT, Van Natta M, Quinn TC, Murphy RL, et al. Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis. J Infect Dis. 2002 Oct 1;186(7):1013–8.
Davidson, Michael, et al. “Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis.J Infect Dis, vol. 186, no. 7, Oct. 2002, pp. 1013–18. Pubmed, doi:10.1086/342956.
Davidson M, Min Y-I, Holbrook JT, Van Natta M, Quinn TC, Murphy RL, Welch W, Jabs DA, Meinert CL, Studies of Ocular Complications of AIDS Research Group. Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis. J Infect Dis. 2002 Oct 1;186(7):1013–1018.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

October 1, 2002

Volume

186

Issue

7

Start / End Page

1013 / 1018

Location

United States

Related Subject Headings

  • Viral Load
  • Treatment Outcome
  • Recombinant Proteins
  • RNA, Viral
  • Neutropenia
  • Microbiology
  • Male
  • Humans
  • HIV-1
  • Granulocyte Colony-Stimulating Factor