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A guide to analysis of mouse energy metabolism.

Publication ,  Journal Article
Tschöp, MH; Speakman, JR; Arch, JRS; Auwerx, J; Brüning, JC; Chan, L; Eckel, RH; Farese, RV; Galgani, JE; Hambly, C; Herman, MA; Horvath, TL ...
Published in: Nat Methods
December 28, 2011

We present a consolidated view of the complexity and challenges of designing studies for measurement of energy metabolism in mouse models, including a practical guide to the assessment of energy expenditure, energy intake and body composition and statistical analysis thereof. We hope this guide will facilitate comparisons across studies and minimize spurious interpretations of data. We recommend that division of energy expenditure data by either body weight or lean body weight and that presentation of group effects as histograms should be replaced by plotting individual data and analyzing both group and body-composition effects using analysis of covariance (ANCOVA).

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Published In

Nat Methods

DOI

EISSN

1548-7105

Publication Date

December 28, 2011

Volume

9

Issue

1

Start / End Page

57 / 63

Location

United States

Related Subject Headings

  • Phenotype
  • Obesity
  • Mice, Mutant Strains
  • Mice
  • Housing, Animal
  • Environment
  • Energy Metabolism
  • Energy Intake
  • Developmental Biology
  • Body Composition
 

Citation

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Tschöp, M. H., Speakman, J. R., Arch, J. R. S., Auwerx, J., Brüning, J. C., Chan, L., … Ravussin, E. (2011). A guide to analysis of mouse energy metabolism. Nat Methods, 9(1), 57–63. https://doi.org/10.1038/nmeth.1806
Tschöp, Matthias H., John R. Speakman, Jonathan R. S. Arch, Johan Auwerx, Jens C. Brüning, Lawrence Chan, Robert H. Eckel, et al. “A guide to analysis of mouse energy metabolism.Nat Methods 9, no. 1 (December 28, 2011): 57–63. https://doi.org/10.1038/nmeth.1806.
Tschöp MH, Speakman JR, Arch JRS, Auwerx J, Brüning JC, Chan L, et al. A guide to analysis of mouse energy metabolism. Nat Methods. 2011 Dec 28;9(1):57–63.
Tschöp, Matthias H., et al. “A guide to analysis of mouse energy metabolism.Nat Methods, vol. 9, no. 1, Dec. 2011, pp. 57–63. Pubmed, doi:10.1038/nmeth.1806.
Tschöp MH, Speakman JR, Arch JRS, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E. A guide to analysis of mouse energy metabolism. Nat Methods. 2011 Dec 28;9(1):57–63.

Published In

Nat Methods

DOI

EISSN

1548-7105

Publication Date

December 28, 2011

Volume

9

Issue

1

Start / End Page

57 / 63

Location

United States

Related Subject Headings

  • Phenotype
  • Obesity
  • Mice, Mutant Strains
  • Mice
  • Housing, Animal
  • Environment
  • Energy Metabolism
  • Energy Intake
  • Developmental Biology
  • Body Composition