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The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis.

Publication ,  Journal Article
Herman, MA; Samuel, VT
Published in: Trends Endocrinol Metab
October 2016

Epidemiological studies link fructose consumption with metabolic disease, an association attributable in part to fructose-mediated lipogenesis. The mechanisms governing fructose-induced lipogenesis and disease remain debated. Acutely, fructose increases de novo lipogenesis through the efficient and uninhibited action of ketohexokinase and aldolase B which yields substrates for fatty-acid synthesis. Chronic fructose consumption further enhances the capacity for hepatic fructose metabolism by activating several key transcription factors (i.e., SREBP1c and ChREBP) which augment the expression of lipogenic enzymes, increasing lipogenesis and further compounding hypertriglyceridemia and hepatic steatosis. Hepatic insulin resistance develops from diacylglycerol-PKCɛ-mediated impairment of insulin signaling and possibly additional mechanisms. Initiatives that decrease fructose consumption and therapies that block fructose-mediated lipogenesis will be necessary to avert future metabolic pandemics.

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Published In

Trends Endocrinol Metab

DOI

EISSN

1879-3061

Publication Date

October 2016

Volume

27

Issue

10

Start / End Page

719 / 730

Location

United States

Related Subject Headings

  • Signal Transduction
  • Lipogenesis
  • Lipid Metabolism
  • Insulin Resistance
  • Insulin
  • Humans
  • Fructose
  • Endocrinology & Metabolism
  • Animals
  • 3215 Reproductive medicine
 

Citation

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Herman, M. A., & Samuel, V. T. (2016). The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis. Trends Endocrinol Metab, 27(10), 719–730. https://doi.org/10.1016/j.tem.2016.06.005
Herman, Mark A., and Varman T. Samuel. “The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis.Trends Endocrinol Metab 27, no. 10 (October 2016): 719–30. https://doi.org/10.1016/j.tem.2016.06.005.
Herman MA, Samuel VT. The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis. Trends Endocrinol Metab. 2016 Oct;27(10):719–30.
Herman, Mark A., and Varman T. Samuel. “The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis.Trends Endocrinol Metab, vol. 27, no. 10, Oct. 2016, pp. 719–30. Pubmed, doi:10.1016/j.tem.2016.06.005.
Herman MA, Samuel VT. The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis. Trends Endocrinol Metab. 2016 Oct;27(10):719–730.
Journal cover image

Published In

Trends Endocrinol Metab

DOI

EISSN

1879-3061

Publication Date

October 2016

Volume

27

Issue

10

Start / End Page

719 / 730

Location

United States

Related Subject Headings

  • Signal Transduction
  • Lipogenesis
  • Lipid Metabolism
  • Insulin Resistance
  • Insulin
  • Humans
  • Fructose
  • Endocrinology & Metabolism
  • Animals
  • 3215 Reproductive medicine