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Choroidal thickness and high myopia: a case-control study of young Chinese men in Singapore.

Publication ,  Journal Article
Gupta, P; Saw, S-M; Cheung, CY; Girard, MJA; Mari, JM; Bhargava, M; Tan, C; Tan, M; Yang, A; Tey, F; Nah, G; Zhao, P; Wong, TY; Cheng, C-Y
Published in: Acta Ophthalmol
November 2015

PURPOSE: To determine the distribution of choroidal thickness (CT) and ocular factors associated with CT in high myopic eyes in comparison with emmetropic eyes of young healthy adults. METHODS: A case-control study of 648 young, male subjects, including 520 high myopes and 128 emmetropes. Choroidal imaging was performed using enhanced depth imaging spectral domain optical coherence tomography. Images were postprocessed using adaptive compensation for quality enhancement. CT was measured at nine locations, including subfovea and 1.5 and 3 mm nasal, temporal, superior and inferior to fovea. RESULTS: The CT at the subfovea was significantly thinner (mean ± standard error: 225.87 ± 5.51 μm) for high myopes compared to emmetropes (375.15 ± 6.58 μm, p < 0.001). Likewise, CT in high myopic group was significantly thinner than emmetropic control group at all locations (p for trend <0.001 for all locations). Distribution of CT showed a markedly different pattern in high myopic eyes (thickest superiorly at 3 mm, 265.97 ± 5.97 μm) and emmetropic eyes (thickest subfoveally, 375.15 ± 6.58 μm). Choroid was thinnest at nasal 3 mm location in both the myopic (108.85 ± 3.97 μm) and emmetropic (238.25 ± 6.72 μm) groups. Among the ocular factors studied, axial length, posterior staphyloma and chorio-retinal atrophy were the significant predictors of CT. CONCLUSIONS: Highly myopic eyes have significantly thinner choroid and showed different distribution pattern, compared to emmetropes. Axial length, posterior staphyloma and chorio-retinal atrophy are the strongest determinants of CT.

Duke Scholars

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Published In

Acta Ophthalmol

DOI

EISSN

1755-3768

Publication Date

November 2015

Volume

93

Issue

7

Start / End Page

e585 / e592

Location

England

Related Subject Headings

  • Young Adult
  • Tomography, Optical Coherence
  • Singapore
  • Retina
  • Organ Size
  • Ophthalmology & Optometry
  • Myopia, Degenerative
  • Male
  • Humans
  • Emmetropia
 

Citation

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ICMJE
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Gupta, P., Saw, S.-M., Cheung, C. Y., Girard, M. J. A., Mari, J. M., Bhargava, M., … Cheng, C.-Y. (2015). Choroidal thickness and high myopia: a case-control study of young Chinese men in Singapore. Acta Ophthalmol, 93(7), e585–e592. https://doi.org/10.1111/aos.12631
Gupta, Preeti, Seang-Mei Saw, Carol Y. Cheung, Michael J. A. Girard, Jean Martial Mari, Mayuri Bhargava, Colin Tan, et al. “Choroidal thickness and high myopia: a case-control study of young Chinese men in Singapore.Acta Ophthalmol 93, no. 7 (November 2015): e585–92. https://doi.org/10.1111/aos.12631.
Gupta P, Saw S-M, Cheung CY, Girard MJA, Mari JM, Bhargava M, et al. Choroidal thickness and high myopia: a case-control study of young Chinese men in Singapore. Acta Ophthalmol. 2015 Nov;93(7):e585–92.
Gupta, Preeti, et al. “Choroidal thickness and high myopia: a case-control study of young Chinese men in Singapore.Acta Ophthalmol, vol. 93, no. 7, Nov. 2015, pp. e585–92. Pubmed, doi:10.1111/aos.12631.
Gupta P, Saw S-M, Cheung CY, Girard MJA, Mari JM, Bhargava M, Tan C, Tan M, Yang A, Tey F, Nah G, Zhao P, Wong TY, Cheng C-Y. Choroidal thickness and high myopia: a case-control study of young Chinese men in Singapore. Acta Ophthalmol. 2015 Nov;93(7):e585–e592.
Journal cover image

Published In

Acta Ophthalmol

DOI

EISSN

1755-3768

Publication Date

November 2015

Volume

93

Issue

7

Start / End Page

e585 / e592

Location

England

Related Subject Headings

  • Young Adult
  • Tomography, Optical Coherence
  • Singapore
  • Retina
  • Organ Size
  • Ophthalmology & Optometry
  • Myopia, Degenerative
  • Male
  • Humans
  • Emmetropia